ANTIARRHYTHMIC DRUGS
TOP 10 MCQ
1. Statement I: In vasospastic angina, the imbalance occurs when the myocardial oxygen requirement increases, as during exercise, and coronary blood flow does not increase proportionately.
Statement II: In Prinzmetal’s angina, oxygen delivery decreases as a result of reversible coronary vasospasm.
In light of the above statements, choose the most appropriate answer from the options given below [GPAT-2023 SHIFT-I]
(a) Both Statement I and Statement II are correct
(b) Both Statement I and Statement II are incorrect
(c) Statement I is correct but Statement II is incorrect
(d) Statement I is incorrect but Statement II is correct
2. Nitric oxide synthase exists in [GPAT-2022]
(a) Two isoforms
(b) Three isoforms
(c) Four isoforms
(d) Five isoforms
3. Which one of the following calcium channel blockers used as anti-anginal agents has the highest possibility to produce a negative inotropic effect, AV nodal block, bradycardia, decreased cardiac output, constipation, edema and is contraindicated in sick sinus syndrome [GPAT-2021]
(a) Nifedipine
(b) Amlodipine
(c) Diltiazem
(d) Verapamil
4. Which one of the following is NOT the role of Nitric oxide [GPAT-2019]
(a) Reliving vascular smooth muscle
(b) Mediating microbicidal action of macrophages
(c) Acting as neurotransmitter in CNS
(d) Inducing platelet aggregation
5. Which of the following side effect of ACE inhibitors result from inhibition of bradykinin break down [GPAT-2018]
(a) Analgesia
(b) Hyperglycaemia
(c) Productive cough
(d) Dry cough
6. Which one of the following drugs produces significant relaxation of both venules and arterioles [GPAT-2012]
(a) Hydralazine
(b) Minoxidil
(c) Diazoxide
(d) Sodium nitroprusside
7. All of the given four drugs cause vasodilation
[P] Bradykinin
[Q] Minoxidil
[R] Acetylcholine
[S] Hydralazine
Choose the correct statement about them [GPAT-2011]
(a) R & Q cause release of nitric oxide
(b) Q & R do not cause release of nitric oxide
(c) P & Q cause release of nitric oxide
(d) P & S cause release of nitric oxide
8. The duration of action of sublingual nitroglycerin tablet is [GATE-2007]
(a) 8–10 hours
(b) 4–8 hours
(c) 10–30 minutes
(d) 3–5 minutes
9. Study the statements and choose the CORRECT answer [GPAT-2015]
[P] Nitroglycerin, related nitrates, and nitroprusside produce vasodilation by nitric oxide-dependent elevation of cyclic GMP in vascular smooth muscle
[Q] The pharmacologic effects of Sildenafil, Tadalafil and Vardenafil result from inhibition of the type 5 isoform of phosphodiesterase that inactivates cGMP
(a) P is correct and Q is incorrect
(b) Both P and Q are correct
(c) Both P and Q are incorrect
(d) P is incorrect and Q is correct
10. A person taking nitroglycerine consumes alcohol. The drug interacts with alcohol and the effect observed is [GPAT-2009]
(a) Severe hypotension and collapse
(b) Drowsiness
(c) Anticoagulant effect
(d) Hypertension
ANSWER KEY
| 1-d | 2-b | 3-d | 4-d | 5-d | 6-d | 7-c | 8-c | 9-c | 10-a |
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