5-HYDROXYTRYPTAMINE, ITS ANTAGONISTS AND DRUG THERAPY OF MIGRANE GPAT MCQs Part – 2

TOP 10 MCQ

1. Vomiting reflex in response to serotonin are mediated by receptors [GPAT-2014, 2024]
(a) 5-HT₁
(b) 5-HT₂
(c) 5-HT₃
(d) 5-HT₄

2. Which of the following is NOT a sulphonamide derivative [GPAT-2023 SHIFT-II]
(a) Almotriptan
(b) Sumatriptan
(c) Rizatriptan
(d) Naratriptan

3. Identify antihistamine drug with additional serotonin receptor blocking activity and good appetite stimulant property [GPAT-2018]
(a) Cyproheptadine
(b) Cimetidine
(c) Ranitidine
(d) Chlorpheniramine

4. 5-HT₂ antagonist is [GPAT-2016]
(a) Clozapine
(b) Ketanserin
(c) Sumatriptan
(d) Cisapride

5. Match drugs with their receptors that they inhibit [GPAT-2015]
5-HT₁A agonist
5-HT₂ antagonist
5-HT₃ antagonist
5-HT₁A agonist
[P] Cisapride
[Q] Ketanserin
[R] Ondansetron
[S] Buspirone
(a) 1-[S], 2-[R], 3-[Q], 4-[P]
(b) 1-[R], 2-[S], 3-[Q], 4-[P]
(c) 1-[P], 2-[R], 3-[S], 4-[Q]
(d) 1-[R], 2-[Q], 3-[P], 4-[S]

6. Following 5-HT receptor is involved in haemostasis accelerating platelet aggregation
(a) 5-HT₂C
(b) 5-HT₂A
(c) 5-HT₁A
(d) 5-HT₄

7. Acute migraine is treated with [GATE-2008]
(a) Prazosin
(b) Formoterol
(c) Sumatriptan
(d) Dopamine

8. The drug chosen is the agonist of [GATE-2008]
(a) α₂ adrenoceptor
(b) α₁ adrenoceptor
(c) M₁ receptor
(d) 5-HT₁B/1D receptor

9. A 5-HT₁D receptor agonist useful in migraine is [GATE-2003]
(a) Sumatriptan
(b) Ketanserin
(c) Ergotamine
(d) Methysergide

10. All 5-HT receptors are heptahelical serpentine receptors except
(a) 5-HT₁
(b) 5-HT₂
(c) 5-HT₃
(d) 5-HT₄

ANSWER KEY