ADRENERGIC TRANSMISSION AND ADRENERGIC DRUGS
TOP 10 MCQ
1. Which of the following drug can produce mydriasis without cycloplegia [GPAT-2023 SHIFT-II]
(a) Atropine
(b) Tropicamide
(c) Homatropine
(d) Ephedrine
2. ______ activates G-protein gated potassium channel resulting in membrane hyperpolarization [GPAT-2023 SHIFT-II]
(a) α-1 adrenergic receptor
(b) α-2 adrenergic receptor
(c) β-1 adrenergic receptor
(d) β-2 adrenergic receptor
3. The β-adrenergic receptor subtype agonist acting at atrioventricular node produces following response [GPAT-2021]
(a) Increases contractility and conduction velocity
(b) Increases automaticity and conduction velocity
(c) Increases contractility and automaticity
(d) Increases conduction velocity and heart rate
4. Which of the following is NOT one of the triad effects of adrenaline leading to rise in blood pressure [GPAT-2020]
(a) A direct myocardial stimulation that increases the strength of ventricular contraction
(b) An increased heart rate (positive chronotropic action)
(c) Vasoconstriction in many vascular beds specially in precapillary resistance vessels of ski
(d) Stimulation of presynaptic alpha-2 adrenoceptor leading to increase sympathetic tone
5. Select the drug which exhibits dual alpha- and beta-adrenergic receptor agonist activities [GPAT-2018]
(a) Terbutaline
(b) Clonidine
(c) Metaproterenol
(d) Dobutamine
6. All the dopaminergic agonists having affinity for Dâ‚‚ receptors are clinically used in following conditions EXCEPT [GPAT-2017]
(a) Obsessive-compulsive disorder
(b) Hyperprolactinemia
(c) Acromegaly
(d) Parkinsonism
7. Match the following adrenergic drugs with their receptor affinity [GPAT-2017]
Epinephrine
Noradrenaline
Phenylephrine
Dobutamine
[P] More α-1, no β-1, β-2 & dopamine
[Q] More α-1 & β-1, less β-2, no dopamine
[R] More β-1 & β-2, no α-1 & dopamine
[S] More α-1 & β-1, no β-2 & dopamine
(a) 1-[Q], 2-[S], 3-[P], 4-[R]
(b) 1-[P], 2-[R], 3-[S], 4-[Q]
(c) 1-[R], 2-[P], 3-[Q], 4-[S]
(d) 1-[S], 2-[Q], 3-[R], 4-[P]
8. Which of the following is rate limiting step in synthesis of catecholamines [GPAT-2016]
(a) Conversion of Dopa to dopamine by dopa decarboxylase
(b) Conversion of tyrosine to L-Dopa in presence of enzyme tyrosine hydroxylase
(c) Conversion of dopamine to NA by dopamine β-hydroxylase
(d) Conversion of noradrenaline to adrenaline by N-methyltransferase
9. Which of the following drugs are often found in both prescription and over the counter nasal decongestants [GPAT-2016]
(a) Alpha 2 agonists
(b) Alpha 1 agonists
(c) Alpha 1 antagonists
(d) Beta 2 agonists
10. Following is an analogue of Amphetamine which produces anorexia without causing stimulation [GPAT-2014]
(a) Fenfluramine
(b) Methyl amphetamine
(c) Methylphenidate
(d) Dextroamphetamine
ANSWER KEY
| 1-d | 2-b | 3-b | 4-d | 5-d | 6-a | 7-a | 8-b | 9-b | 10-a |
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