ADVERSE DRUG EFFECTS GPAT MCQs Part – 5

TOP 10 MCQ

1. Monitoring of plasma drug concentration is required while using [GPAT-2024]
(a) Antihypertensive drugs
(b) Levodopa
(c) Lithium carbonate
(d) MAO inhibitors

2. Match the following cells of immune system List I with their functions List II [GPAT-2023 SHIFT-I]
List I (Immune system)                                 List II (Functions)
Mast cell                                                            [P] Master of immune system
Lymphocytes                                                    [Q] Allergic reactions
T-cells                                                                [R] Cell mediated immune reaction
Monocytes–Macrophages                              [S] Antigen recognition, Phagocytosis
Choose the correct answer from the options given below
(a) 1-[P], 2-[Q], 3-[R], 4-[S]
(b) 1-[Q], 2-[P], 3-[R], 4-[S]
(c) 1-[R], 2-[P], 3-[Q], 4-[S]
(d) 1-[P], 2-[R], 3-[Q], 4-[S]

3. Phaeomelia is caused by [GPAT-2023 SHIFT-II]
(a) Glibenclamide
(b) Indapamide
(c) Xipamide
(d) Thalidomide

4. Which of the following statements are TRUE with the Adverse Drug Reactions
[A] Any response to a drug which is noxious and unintended
[B] Which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of a disease
[C] Adverse drug event is same as that of Adverse Drug Reaction
[D] Which occurs at normal dose or overdose when used for prophylaxis, diagnosis or therapy of a disease
Choose the CORRECT answer from the options given below [GPAT-2022]
(a) A and B are true while C and D are false
(b) A and C are true while B and D are false
(c) B, C and D are false, Only A is true
(d) A, B and C are false, Only D is true

5. The management of Type-B adverse drug reaction is [GPAT-2018]
(a) To reduce the dose
(b) To withhold the dose and avoid in future
(c) To reintroduce and withdraw slowly
(d) To increase the dose

6. Loss of therapeutic efficacy after prolonged/intensive use of drug [GPAT-2016]
(a) Refractoriness
(b) Resistance
(c) Tachyphylaxis
(d) Idiosyncrasy

7. A direct way of studying idiosyncratic reactions to the given drug is by [GATE-2004]
(a) Changing the route of drug administration
(b) Change the assay method
(c) Pharmacogenomics
(d) Structure activity relationship studies of a family of compounds

8. One of the following types of adverse drug reactions is NOT believed to be dose related phenomena [GATE-1995]
(a) Side effects and toxic reactions
(b) Toxic reactions and hypersensitivity
(c) Side effects and hypersensitivity
(d) Hypersensitivity and idiosyncrasy

9. Arthus reaction is which type of allergic reaction
(a) Humoral – Type I
(b) Humoral – Type II
(c) Humoral – Type III
(d) Cell mediated – Type IV

10. Following is type B adverse drug reaction
(a) Side effect
(b) Idiosyncrasy
(c) Toxic effect
(d) Dependence

ANSWER KEY