ANTI-RHEUMATOID AND ANTIGOUT DRUGS
TOP 10 MCQ
1. Anti-rheumatoid drug which is contraindicated in patients with renal and hepatic impairment [GPAT-2023 SHIFT-III]
(a) Sulfasalazine
(b) Methotrexate
(c) Corticosteroids
(d) Azathioprine
2. Abatacept, a fusion protein, and a co-stimulation blocker used in the treatment of rheumatoid arthritis blocks the [GPAT-2018]
(a) Activation of T-cells
(b) Inhibition of T-cells
(c) Activation of B-cells
(d) Inhibition of B-cells
3. An 80-year-old lady from osteoarthritis of hip and knee joints is given diclofenac 50 mg thrice daily and paracetamol 1 g as required. She complains of passing black stools. This symptom is due to [GPAT-2006, 2016]
(a) Paracetamol causing black stools
(b) Change in food habits
(c) Upper gastrointestinal bleeding due to diclofenac
(d) Age related decreases in GI motility
4. Which of the following drug prevents uric acid synthesis by inhibiting enzyme xanthine oxidase [GPAT-2015]
(a) Paracetamol
(b) Allopurinol
(c) Sulfasalazine
(d) Aspirin
5. Which of the following used in the treatment of rheumatoid arthritis is NOT a biologic response modifier [GPAT-2015]
(a) Anakinra
(b) Leflunomide
(c) Etanercept
(d) Infliximab
6. Which of the following cytokines are the most important regulators in inflammation and are the targets for anti-inflammatory agents used in rheumatoid arthritis [GPAT-2012]
(a) Tumor necrosis factor-α and Interleukin-1
(b) Leukotrienes and Isoprostanes
(c) Acetylcholine esterase and Eicosanoids
(d) Adhesion factor and Monoamine oxidase A
7. Choose the CORRECT statement about the given four diseases [GPAT-2011]
[P] Cardiomyopathy
[Q] Rheumatoid arthritis
[R] Myasthenia gravis
[S] Ulcerative colitis
(a) Q & S are autoimmune disorders
(b) P & Q are autoimmune disorders
(c) P & R are not autoimmune disorders
(d) R & S are not autoimmune disorders
8. Which of the following used in the treatment of rheumatoid arthritis is NOT a biologic response modifier [GPAT-2011]
(a) Anakinra
(b) Leflunomide
(c) Etanercept
(d) Infliximab
9. Interleukins are [GATE-2009]
(a) Polypeptide cytokines important in the inflammatory cascade
(b) Prostaglandins that account for gastrointestinal disorders
(c) Enkephalins which are specific for asthma
(d) Dipeptides which have antimicrobial properties
10. A patient with rheumatoid arthritis has been taking acetyl salicylic acid regularly. However, recently she has been experiencing stiffness, swelling and pain due to salicylate resistance. She has occult blood in her faeces. Suggest an appropriate drug suitable for her from below [GATE-2004]
(a) Paracetamol
(b) Celecoxib
(c) Piroxicam
(d) Naproxen
ANSWER KEY
| 1-b | 2-a | 3-c | 4-b | 5-b | 6-a | 7-b | 8-b | 9-a | 10-b |
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