ANTICHOLINERGIC DRUGS AND DRUGS ACTING ON AUTONOMIC GANGLIA
TOP 10 MCQ
1. Which among the following is an amino-alcohol analogue that has weak visceral anticholinergic activity but is a strong nicotinolytic drug [GPAT-2023 SHIFT-II]
(a) Biperiden
(b) Orphenadrine
(c) Fodine
(d) Propantheline
2. Reason for the combination of Diphenoxylate (2.5 mg) + Atropine (0.025 mg) is to [GPAT-2022]
(a) Inhibits the side effects of Diphenoxylate
(b) Discourage abuse of Diphenoxylate
(c) Augment the anti-motility action of Diphenoxylate
(d) Suppress gastroenteritis-related vomiting
3. Which three of the following are physiological effects of ganglionic stimulating agents [GPAT-2020]
[P] Stimulation of sympathetic ganglia and the adrenal medulla leading to cardiovascular response
[Q] Initial transient stimulation and then a more persistent depression of all autonomic ganglia
[R] Marked depression of CNS leading to analgesia
[S] Chronic exposure causes a marked increase in the density of nicotinic receptors contributing tolerance and dependence
[T] Combined activation of parasympathetic ganglia and cholinergic nerve ending by nicotine results in increased tone and motor activity of the bowel
[U] Inhibition of salivary and bronchial secretions that is followed by stimulation
(a) [P], [R] and [S]
(b) [P], [S] and [U]
(c) [Q], [R] and [T]
(d) [P], [Q] and [S]
4. Following are the facts regarding clinical applications of muscarinic receptor blocking drugs. Identify the false statement [GPAT-2019]
(a) Used in the treatment of Parkinson’s disease is often an exercise in polypharmacy, since no single agent is fully effective
(b) Marked reflex vagal discharge may stimulate sinoatrial or atrioventricular node to improve cardiac output
(c) Mydriasis produced greatly facilitates ophthalmoscopic examination of the retina and measurement of refractive error in uncooperative patient
(d) Scopolamine is one among the old remedies used to treat sea-sickness
5. The antiemetic activity of glycopyrronium is related to potent inhibition of receptor both peripherally and centrally [GPAT-2019]
(a) 5HT₃
(b) D₂
(c) M₁
(d) H₁
6. To obtain a more effective bronchodilation, the drugs that are combined along with beta-adrenoceptor agonists are [GPAT-2018]
(a) Cholinergic antagonists
(b) Cholinergic agonists
(c) Beta-adrenoceptor antagonists
(d) Alpha-adrenoceptor antagonists
7. Drug of choice for smoking cessation [GPAT-2013]
(a) Varenicline
(b) Duloxetine
(c) Acamprosate
(d) Chlordiazepoxide
8. Which one of the following classes of drugs causes side effects like dryness of mouth, tachycardia, urinary retention, constipation, blurring of vision, precipitation of glaucoma, drowsiness and impairment of cognition [GPAT-2012]
(a) Anti-adrenergic
(b) Anti-cholinergic
(c) Anti-serotonergic
(d) Anti-dopaminergic
9. Myasthenia gravis is diagnosed with improved neuromuscular function by using [GPAT-2010]
(a) Donepezil
(b) Edrophonium
(c) Atropine
(d) Pancuronium
10. (−)-Hyoscyamine is [GATE-2008]
(a) 15–20 times more active as a mydriatic than (+)-hyoscyamine
(b) Inactive as a mydriatic
(c) 3–5 times less active as a mydriatic than (+)-hyoscyamine
(d) 100 times more active as a mydriatic than (+)-hyoscyamine
ANSWER KEY
| 1-a | 2-b | 3-d | 4-b | 5-c | 6-a | 7-a | 8-b | 9-b | 10-a |
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