ANTIDEPRESSENT AND ANTIANXITY
TOP 10 MCQ
1. Which antidepressant drug acts through α₁ blocking action [GPAT-2014, 2024]
(a) Trazodone
(b) Maprotiline
(c) Bupropion
(d) Mirtazapine
2. Which one of these combinations is MAO inhibitor [GPAT-2014, 2024]
(a) Tranylcypromine, Phenelzine, Isocarboxazid
(b) Amoxapine, Phenelzine, Amitriptyline
(c) Fluoxetine, Phenelzine, Isocarboxazid
(d) Amitriptyline, Phenelzine, Isocarboxazid
3. Which of the following is a tetracyclic antidepressant that has added dopamine D₂ receptor blocking and neuroleptic properties as well as a greater tendency to cause seizure in overdose [GPAT-2023 SHIFT-I | REPEATED QUESTION]
(a) Dotiepin
(b) Doxepin
(c) Trazodone
(d) Amoxapine
4. Venlafaxine is an FDA approved drug for the treatment of
(a) Schizophrenia
(b) Major depressive disorder
(c) Mania
(d) Anxiety
5. What secondary changes are associated with long-term SSRI treatment and contribute to their antidepressant effects?
(a) Upregulation of presynaptic 5-HT₁A autoreceptors
(b) Increased activation of 5-HT₂ receptors
(c) Indirect enhancement of norepinephrine (NE) output
(d) Decreased production of brain-derived neurotrophic factor (BDNF)
6. Which of the following are the critical neurotransmitters playing a role in depression [GPAT-2012]
(a) Acetylcholine, Norepinephrine and Dopamine
(b) Norepinephrine and Serotonin
(c) Serotonin, Dopamine and γ-amino butyric aci
(d) Acetylcholine, Serotonin and γ-amino butyric acid
7. Selective serotonin reuptake inhibitor is [GPAT-2010]
(a) Imipramine
(b) Iproniazid
(c) Fluoxetine
(d) Naphazoline
8. There are many types of antidepressants. Some are long acting, while some are short acting. An example of a short acting antidepressant drug is [GATE-2006]
(a) Fluoxetine
(b) Valproate
(c) Etorphine
(d) Moclobemide
9. The drug selected above acts by [GATE-2006]
(a) Inhibiting MAO-A
(b) Inhibiting NA/5-HT reuptake
(c) Blocking 5-HT₁ receptors
(d) Inhibiting ACE
10. A selective serotonin reuptake inhibitor used as an antidepressant is [GATE-2005]
(a) Sertraline
(b) Selegiline
(c) Phenelzine
(d) Amoxapine
ANSWER KEY
| 1-d | 2-a | 3-d | 4-b | 5-c | 6-b | 7-c | 8-d | 9-a | 10-a |
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