ANTIEMETIC, PROKINETIC AND DIGESTANT DRUGS
TOP 10 MCQ
1. All the following are true with Metoclopramide EXCEPT [GPAT-2023 SHIFT-I]
(a) 5-HT₃ receptor antagonist
(b) D₂ receptor antagonist
(c) 5-HT₄ receptor agonist
(d) 5-HT₁ receptor agonist
2. Metoclopramide is generally used for [GATE-2004]
(a) Prophylaxis of vomiting
(b) Preventing motion sickness
(c) Treating irritable bowel syndrome
(d) Treatment of pancreatic insufficiency
3. The most effective antimotion sickness drug suitable for short brisk journeys is
(a) Promethazine theoclate
(b) Cinnarizine
(c) Hyoscine
(d) Prochlorperazine
4. Chlorpromazine and its congeners suppress vomiting of following etiologies EXCEPT
(a) Motion sickness
(b) Radiation sickness
(c) Postanaesthetic
(d) Uremic
5. Metoclopramide has the following actions EXCEPT
(a) Increases lower esophageal sphincter
(b) Increases tone of pyloric sphincter
(c) Increases gastric peristalsis
(d) Increases intestinal peristalsis
6. Metoclopramide
(a) Inhibit cholinergic smooth muscle stimulation in the gastrointestinal tract
(b) Decrease lower esophageal sphincter pressure
(c) Stimulate D₂ receptor
(d) Enhance gastric motility
7. Which drug can lead to prolongation of QT interval
(a) Domperidone
(b) Metoclopramide
(c) Cisapride
(d) Omeprazole
8. Which prokinetic drug(s) produce(s) extrapyramidal side effects
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) All of the above
9. Which antiemetic selectively blocks levodopa induced vomiting without blocking its antiparkinsonian action
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) Ondansetron
10. The fastest symptomatic relief as well as highest healing rates in reflux esophagitis are obtained with
(a) Prokinetic drugs
(b) H₂ receptor blockers
(c) Proton pump inhibitors
(d) Sodium alginate
ANSWER KEY
| 1-a | 2-a | 3-d | 4-a | 5-b | 6-d | 7-c | 8-a | 9-c | 10-c |
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