ANTIEPILEPTIC DRUGS
TOP 10 MCQ
1. Which of the following drug is the first choice in status epilepticus? [GPAT-2014, 2024]
(a) Benzodiazepine
(b) Phenytoin
(c) Thiopentone and propofol
(d) All of these
2. Identify the drug that is not among the drugs recommended as first-line drug in the treatment of Partial seizure with or without generalization [GPAT-2023 SHIFT-I]
(a) Carbamazepine
(b) Valproate
(c) Diazepam
(d) Lamotrigine
3. Valproate and Carbamazepine can be used as first line drugs for the management of following type of seizure [GPAT-2023 SHIFT-I]
(a) Both partial seizure and tonic-clonic seizure
(b) Both tonic-clonic seizure and status epilepticus
(c) Only febrile seizures
(d) Both febrile seizures and status epilepticus
4. A neonate suffering from icterus is intravenously administered with Phenobarbital. The justification for this therapy is [GPAT-2022]
(a) Phenobarbital is a short acting barbiturate and hence safe to induce sleep in neonates
(b) Phenobarbital suppresses the bilirubin synthesis in neonates
(c) Phenobarbital suppresses hepatic glucuronyl transferase and increases clearance of bilirubin
(d) Phenobarbital induces hepatic glucuronyl transferase and increases clearance of bilirubin
5. Vigabatrin produces anti-epileptic activity through [GPAT-2021]
(a) Potentiating GABA mediated inhibition by depressing GABA transporters
(b) Blocking NMDA receptors for glutamate/GABA by binding to a specific synaptic protein
(c) Inhibiting GABA transaminase enzyme which degrades GABA
(d) Potentiating post synaptic GABA receptor effect
6. The mechanism of antiepileptic effect of Lamotrigine is by [GPAT-2020]
(a) Inhibition of glutamate release
(b) Blockade of NMDA receptors
(c) Inhibition of Na⁺ channels
(d) Inhibition of Ca²⁺ channels
7. Identify the false statement about Benzodiazepines from the following [GPAT-2019]
(a) Benzodiazepines cause reduction of anxiety
(b) Benzodiazepines cause convulsion
(c) Benzodiazepines cause muscle relaxation and loss of motor co-ordination
(d) Benzodiazepines are useful in insomnia
8. Which of the following anticonvulsants have both inhibition of excitatory glutamatergic synapse and facilitation of GABA mediated Cl⁻ channel opening action [GPAT-2019]
(a) Valproate
(b) Ethosuximide
(c) Topiramate
(d) Phenytoin
9. Vigabatrin is a GABA analogue that potentiates action of GABA in the brain because it [GPAT-2015]
(a) Binds to GABA receptor and acts as agonist
(b) Inhibits GABA transaminase
(c) Blocks NMDA receptor via the glycine binding site
(d) Inhibits neuronal reuptake of GABA from synapses
10. Which of the following drug is the first choice in tonic seizures
(a) Valproate
(b) Phenytoin
(c) Thiopentone and propofol
(d) All of these
ANSWER KEY
| 1-a | 2-c | 3-a | 4-d | 5-c | 6-c | 7-b | 8-c | 9-b | 10-a |
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