ANTIFUNGAL DRUGS
TOP 10 MCQ
1. Antifungal agent 5-fluorocytosine is converted to its active metabolite 5-fluorouracil by one of the following fungal enzymes [GPAT-2020]
(a) Cytosine deacetylase
(b) Cytosine reductase
(c) Cytosine demethylase
(d) Cytosine deaminase
2. Terbinafine acts as [GPAT-2016]
(a) Competitive inhibitor of squalene epoxidase
(b) Noncompetitive inhibitor of squalene epoxidase
(c) Competitive inhibitor of folate synthetase
(d) Noncompetitive inhibitor of folate synthetase
3. Gynecomastia and menstrual irregularities are the adverse effects of [GPAT-2015]
(a) Terbinafine
(b) Flucytosine
(c) Griseofulvin
(d) Ketoconazole
4. Which antifungal acts by non-competitive inhibition of squalene epoxidase thereby inhibition of ergosterol synthesis [GPAT-2013]
(a) Caspofungin
(b) Amphotericin B
(c) Terbinafine
(d) Ketoconazole
5. Group I – Group II [GATE-2008]
Drugs                           Mechanisms
Terbinafine             [P] Inhibition of reverse transcriptase
Cidofovir               [Q] Selective inhibition of squalene epoxidase
Imatinib                [R] Inhibition of DNA polymerase
Stavudine               [S] Tyrosine kinase inhibitor
(a) 1-P, 2-Q, 3-R, 4-S
(b) 1-S, 2-R, 3-Q, 4-P
(c) 1-Q, 2-R, 3-S, 4-P
(d) 1-R, 2-Q, 3-P, 4-S
6. One of the drugs when coadministered with Terfenadine may lead to life threatening cardiac arrhythmia [GATE-2001]
(a) Lomefloxacin
(b) Clofazimine
(c) Itraconazole
(d) Neomycin
7. Mechanism of action of triazoles
(a) Inhibit ergosterol synthesis
(b) Inhibit cell wall synthesis
(c) Inhibit nucleic acid synthesis
(d) Interferes with mitosis
8. Amphotericin B acts on
(a) Fungal cell wall
(b) Fungal cell membrane
(c) Fungal nucleic acid
(d) Fungal 30S ribosome
9. Antifungal drug Nikkomycin acts by
(a) Inhibit ergosterol synthesis
(b) Disrupts membrane function
(c) Inhibit chitin synthesis
(d) Inhibit mitosis
10. Antifungal drug used for systemic fungal infection is
(a) Griseofulvin
(b) Clotrimazole
(c) Amphotericin B
(d) Econazole
ANSWER KEY
| 1-d | 2-b | 3-d | 4-c | 5-c | 6-a | 7-a | 8-b | 9-c | 10-c |
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