ANTITUBERCULAR DRUGS
TOP 10 MCQ
1. Identify the drug which is NOT useful in the treatment of tuberculosis [GPAT-2019]
(a) Pyrazinamide
(b) Gentamicin
(c) Streptomycin
(d) Ciprofloxacin
2. Neuropathy is adverse effect of [GPAT-2016]
(a) Isoniazid
(b) Ethambutol
(c) Pyrazinamide
(d) Dapsone
3. One of the following pairs of “mechanism” is most accurate [GPAT-2014]
(a) Streptomycin: Miscoding in bacterial protein synthesis
(b) Ritonavir: Inhibition of reverse transcriptase in HIV
(c) Nystatin: Decreased synthesis of ergosterol in fungal cell membranes
(d) Tetracycline: Inhibits the activity of peptidyl transferase in bacterial protein
4. Bacillus subtilis is used in assay of which antibiotics [GPAT-2015]
(a) Penicillin
(b) Cephalosporin
(c) Vancomycin
(d) Streptomycin
5. NOT a hepatotoxic drug [GPAT-2013]
(a) Chlorpropamide
(b) Allopurinol
(c) Streptomycin
(d) Halothane
6. A 55-years old man is under DOTS treatment for pulmonary tuberculosis for the last four months. Now he has developed symptoms of peripheral neuritis. Which one of the following is the right addition to his therapy to manage peripheral neuritis [GPAT-2012]
(a) Cyanocobalamin
(b) α-Lipoic acid
(c) Pyridoxine
(d) Prednisolone
7. The given antibiotic is an example of Ansamycins [GPAT-2010]
(a) Roxythromycin
(b) Adriamycin
(c) Aureomycin
(d) Rifamycin
8. Streptomycin can NOT be given orally for treatment of tuberculosis because [GPAT-2010]
(a) It gets degraded in the GIT
(b) It causes severe diarrhea
(c) It causes metallic taste in the mouth
(d) It is not absorbed from the GIT
9. A drug which inhibits mycobacterial RNA polymerase and is very useful in treating Mycobacterium avium complex is [GPAT-2004]
(a) Isoniazid
(b) Ethionamide
(c) Capreomycin
(d) Rifabutin
10. Isoniazid is a primary antitubercular agent that [GPAT-2000]
(a) Requires pyridoxine supplementation
(b) Causes ocular complication that are reversible if the drug is discontinued
(c) Is ototoxic and nephrotoxic
(d) Should never be used due to its hepatotoxicity potential
ANSWER KEY
| 1-b | 2-a | 3-a | 4-d | 5-c | 6-c | 7-d | 8-d | 9-d | 10-a |
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