APPLICATION OF PHARMACOKINETICS PRINCIPLES
TOP 10 MCQ
1. The loading dose (L) of a drug is usually based on the [GPAT-2015]
(a) Total body clearance of the drug
(b) Percentage of drug bound to plasma proteins
(c) Fraction of drug excreted unchanged in the urine
(d) Apparent volume of distribution & desired drug concentration in plasma
2. The release of maintenance dose in sustained release dosage form should follow
(a) Zero-order kinetics
(b) First-order kinetics
(c) Second-order kinetics
(d) Pseudo-order kinetics
3. Therapeutic window refer t
(a) Time interval between administration & the beginning of activity
(b) Concentration difference between drug’s MTC & MEC
(c) Time period before administration of the next dose
(d) Concentration which must be reached before activity begins
4. Which of the following drugs are lipid soluble
(a) Phenytoin
(b) Caffeine
(c) Digoxin
(d) Antibiotics
5. Which of the following drug distributed to the same extent in both lean and adipose tissue
(a) Phenytoin
(b) Caffeine
(c) Digoxin
(d) Antibiotics
6. Which of the following drug can get distributed in the excess body space
(a) Phenytoin
(b) Caffeine
(c) Digoxin
(d) Antibiotics
7. The therapeutic index is defined as which optimizes therapy
(a) The concentration of drug in plasma
(b) The amount of pathologic symptoms obtained by use of a specific drug
(c) The ratio of effect of the drug versus other drugs for the same disease
(d) The ratio between the average toxic dose and the average therapeutic dose
8. Biotransformation is the process of converting the parent drug to one or more metabolites. Which of the following statements is/are true
(a) The metabolites are usually more polar
(b) Usually, metabolism takes place in the liver and kidney
(c) Metabolites are usually less active than parent drug
(d) All of the above
9. The most prominent physiologic factor(s) which influence drug disposition include(s)
(a) Body weight
(b) Age
(c) Temperature
(d) All of the above
10. Which of the following drug does not require therapeutic drug monitoring
(a) Digitoxin
(b) Gentamycin
(c) Phenytoin
(d) Paracetamol
ANSWER KEY
| 1-d | 2-a | 3-b | 4-a | 5-b | 6-c | 7-d | 8-d | 9-d | 10-d |
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