PROTEIN BINDING OF DRUGS
TOP 10 MCQ
1. Conjugation of a drug includes the following EXCEPT [GPAT-2023 SHIFT-III]
(a) Glucuronidation
(b) Sulfonation
(c) Methylatio
(d) Hydrolysis
2. Which mechanism of metabolism of drug is not affected by weight change of patient [GPAT-2019]
(a) Conjugative metabolism
(b) Acetylation metabolism
(c) Hydrolytic metabolism
(d) Oxidative metabolism
3. Which of the following is a phase II drug metabolism reaction associated with genetic polymorphism [GPAT-2016]
(a) Glucuronidation
(b) Acetylation
(c) Reduction
(d) Glutathione conjugation
4. Match the following terms with the definitions given [GATE-2000]
1. Biological half life
2. Therapeutic index
[P] Ratio of the median lethal dose to the median effective dose
[Q] Dosage used in the treatment
[R] Elimination of the drug to 50% of its original concentration
[S] Time taken for a drug to be absorbed
Options:
(a) 1-[Q], 2-[S]
(b) 1-[R], 2-[S]
(c) 1-[R], 2-[P]
(d) 1-[P], 2-[S]
5. The biological half-life of drug [GATE-1991]
(a) It is a constant physical property of the drug
(b) It is a constant chemical property of the drug
(c) It may be increased in patients with impaired renal failure
(d) It may be decreased in patients by giving the drug by rapid IV injection
6. Diazepam gets metabolized into Hydroxydiazepam is example of
(a) Oxidation at allylic carbon atom
(b) Oxidation at the carbon alpha to carbonyl and imino group
(c) Oxidation at benzylic carbon atom
(d) Aromatic and side chain hydroxylation
7. ______ reaction is most common in drugs having ester or amide functional groups
(a) Oxidative reactions
(b) Reduction
(c) Hydrolysis
(d) Phase I
8. What test uses microsomal extracts from the ER for in vitro drug metabolism studies
(a) Ames test
(b) Biochemical tests
(c) Serology
(d) Polymorphisms
9. Which one of the following is not an environmental agent to decrease drug metabolizing ability
(a) DDT
(b) Cigarette smoke
(c) Organophosphate insecticides
(d) Methacholine
10. Oxidation of Hexobarbital results in
(a) 2-hydroxy Hexobarbital
(b) 3-hydroxy Hexobarbital
(c) 4-hydroxy Hexobarbital
(d) 2,3-Dihydroxy Hexobarbital
ANSWER KEY
| 1-d | 2-d | 3-b | 4-c | 5-c | 6-b | 7-c | 8-a | 9-d | 10-c |
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