CARDIAC GYLCOSIDES AND DRUGS FOR HEART FAILURE
TOP 10 MCQ
1. Which of the following are the mechanisms of action of digitalis glycosides [GPAT-2018]
[I] Inhibition of Na⁺–K⁺ ATPase enzyme
[II] Reduction in the auriculo-ventricular conduction rate
[III] Increase in the cardiac output
[IV] Acceleration of auriculo-ventricular conduction rate
(a) Only III
(b) I, II and III
(c) II, III and IV
(d) Only I
2. The risk of digitalis toxicity is significantly increased by concomitant administration of [GPAT-2016]
(a) Triamterene
(b) Lidocaine
(c) Captopril
(d) Hydrochlorothiazide
3. Digitalis given to atrial flutter often produces [GPAT-2013]
(a) Atrial fibrillation
(b) Atrial tachycardia
(c) Atrial asystole
(d) Atrial bigeminy
4. The agent that can only be given intravenously for heart failure is [GPAT-2013]
(a) Digoxin
(b) Amiodarone
(c) Quinidine
(d) Dobutamine
5. Which of the following drugs has positive inotropic & negative chronotropic action [GPAT-2012]
(a) Dopamine
(b) Epinephrine
(c) Digoxin
(d) Isoprenaline
6. Which one of the following therapeutic classes has been proved clinically as a first line therapy for heart failure and has shown decreased hospitalization, improved symptoms and delayed disease progression [GPAT-2012]
(a) Cardiac glycosides
(b) ACE inhibitors
(c) Renin antagonists
(d) Nitrites
7. The risk of digitalis toxicity is significantly increased by concomitant administration of [GATE-2003]
(a) Triamterene
(b) Lidocaine
(c) Captopril
(d) Hydrochlorothiazide
8. The mechanism of Digitalis is [GATE-2001]
(a) Decreases intracellular Na concentration
(b) Inhibits Na⁺–K⁺ ATPase
(c) Activated adenyl cyclase which produces CAMP
(d) Decreases release of Calcium from Sarcoplasmic reticulum
9. In congestive cardiac failure, digitalis glycosides are used because it increases [GATE-1991]
(a) The heart rate
(b) The force of myocardial contraction
(c) The venous pressure
(d) The cardiac filling pressure
10. Digoxin [GATE-1991]
(a) Has its action terminated by metabolism in the liver
(b) Has a plasma t½ of 6 hours
(c) Should be given half of its normal dose to hypothyroid patients
(d) Provides benefit in atrial fibrillation by increasing the force of contraction
ANSWER KEY
| 1-b | 2-d | 3-a | 4-d | 5-c | 6-b | 7-d | 8-b | 9-b | 10-d |
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