CHOLINERGIC DRUGS
TOP 10 MCQ
1. Organophosphorous insecticides are highly toxic substances which affect nervous system. Their mechanism of action is [GPAT-2024]
(a) They block the proton pump
(b) They inhibit Na⁺-K⁺ ATPase
(c) They inhibit ion channels
(d) They irreversibly bind to catalytic site of acetylcholine esterase
2. Pralidoxime chloride is a drug that [GPAT-2024]
(a) Reduces the vesicular stores of catecholamines in adrenergic and dopaminergic neurons
(b) Blocks the active transport of choline into cholinergic neurons
(c) Reactivates cholinesterase that have been inhibited by organophosphate cholinesterase inhibitors
(d) Stimulates the activity of phospholipase C with increased formation of inositol triphosphate
3. Fight or Flight responses are mediated by [GPAT-2023 SHIFT-II]
(a) Parasympathetic division of autonomic nervous system
(b) Sympathetic division of autonomic nervous system
(c) Serotonergic nervous system
(d) Histaminergic nervous system
4. One of the following matches is CORRECT choose it [GPAT-2023 SHIFT-III]
(a) M1 acetylcholine receptors confined to brain; M2 acetylcholine receptors neural; M3 acetylcholine receptors are cardiac; M4 acetylcholine
receptors glandular
(b) M1 acetylcholine receptors neural; M2 acetylcholine receptors confined to brain; M3 acetylcholine receptors are cardiac; M4 acetylcholine
receptors glandular
(c) M1 acetylcholine receptors neural; M2 acetylcholine receptors cardiac; M3 acetylcholine receptors are cardiac to glandular; M4 acetylcholine
receptors confined to brain
(d) M1 acetylcholine receptors glandular; M2 acetylcholine receptors neural; M3 acetylcholine receptors are cardiac to brain; M4 acetylcholine
receptors cardiac
5. Which one of the following interferes with the release of cholinergic neurotransmitter, acetylcholine by the neurons of autonomic nervous system [GPAT-2023 SHIFT-II]
(a) Reserpine
(b) Guanethidine
(c) Hemicholinium
(d) Botulinum toxin
6. One of the following statements with respect to Carbachol is NOT CORRECT Identify [GPAT-2020]
(a) It can be administered orally
(b) It possesses both muscarinic and nicotinic action
(c) It is more susceptible to hydrolysis as compared to acetylcholine
(d) The amino group decreases electrophilicity of the carbonyl group
7. Which of the following is NOT CORRECT for myasthenia gravis [GPAT-2018]
(a) Down regulation of nicotinic receptors (n) leads to myasthenia gravis
(b) Tubocurarine is used to treat myasthenia gravis
(c) It is an autoimmune disorder
(d) Thymectomy is treatment option for myasthenia gravis
8. Which of the following is a shortest acting cholinesterase inhibitor enlisted below [GPAT-2018]
(a) Neostigmine
(b) Pyridostigmine
(c) Edrophonium
(d) Physostigmine
9. Identify the CORRECT pair from the following [GPAT-2018]
(a) Sympathetic stimulation: Bronchoconstriction
(b) Parasympathetic stimulation: Secretion of gastric juice
(c) Sympathetic stimulation: Contraction of pupil
(d) Parasympathetic stimulation: Dilatation of pupil
10. Acetyl Choline is hydrolyzed by enzyme [GPAT-2017]
(a) Acetylase
(b) Cholinesterase
(c) Acetylcholine esterase
(d) Transferase
ANSWER KEY
| 1-d | 2-c | 3-b | 4-c | 5-d | 6-c | 7-b | 8-c | 9-b | 10-c |
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