COMPARTMENT MODELLING
TOP 10 MCQ
1. In pharmacokinetic models, the term “Compartment” means [GPAT-2023]
(a) Blood
(b) Individual organ
(c) Extracellular fluid
(d) Hypothetical pool of tissue
2. In case of open model intravenous infusion, Css (steady state plasma concentration) is equal to [GPAT-2019]
(a) Infusion rate / Clearence
(b) Infusion rate / Clearance
(c) Clearance / Infusion rate
(d) Infusion rate / Clearance
3. When Ka is constant and K is larger [GPAT-2018]
(a) Cmax is more and tmax is longer
(b) Cmax is lesser and tmax is longer
(c) Cmax is more and tmax is short
(d) Cmax is lesser and tmax is short
4. During determination of absorption rate constant by method of residual, flip-flop phenomenon occur when Ka (absorption rate constant) and Ke (overall elimination rate constant): [GPAT-2018]
(a) KE / Ka ≥ 3
(b) Ka / KE ≥ 3
(c) KE / Ka ≥ 3
(d) Ka / KE ≤ 3
5. Elimination after 4 half-lives in first order kinetics is [GPAT-2015]
(a) 84%
(b) 93%
(c) 80.5%
(d) 4.75%
6. An antibiotic which has a half-life of one day is formulated as a 200 mg tablet. How many mg of antibiotic would remain after six days [GPAT-2015]
(a) 12.5 mg
(b) 6.25 mg
(c) 3.12 mg
(d) 1.56 mg
7. Which pharmacokinetic parameter is estimated directly from the log-linear plasma concentration vs time curve in a one-compartment model?
(a) Clearance
(b) Elimination rate constant (k)
(c) Volume of distribution
(d) Bioavailability
8. What will be the dose required maintaining therapeutic concentration of 20 µg/ml for 24 hr of a drug exhibiting total clearance of 2 L/hr [GPAT-2011]
(a) 96 mg
(b) 480 mg
(c) 960 mg
(d) 48 mg
9. A drug is administered to a 65 kg patient as 500 mg tablets every 4 hours. Half-life of the drug is 3 h, volume of distribution is 2 L/kg and oral bioavailability of the drug is 0.85. Calculate the steady state concentration of the drug [GPAT-2011]
(a) 5.05 mcg/ml
(b) 4.50 mcg/ml
(c) 3.53 mcg/ml
(d) 3.00 mcg/ml
10. Drugs following one-compartment open model pharmacokinetics eliminate [GPAT-2010]
(a) Bi-exponentially
(b) Tri-exponentially
(c) Non-exponentially
(d) Mono-exponentially
ANSWER KEY
| 1-d | 2-b | 3-d | 4-a | 5-b | 6-b | 7-b | 8-c | 9-c | 10-d |
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