DISSOLUTION
TOP 10 MCQ
1. According to Noyes-Whitney’s equation, the factor that affects the dissolution is:
(a) Intrinsic solubility
(b) Surface area
(c) Temperature
(d) Viscosity
2. From the point of view of dissolution, which of the following dosage forms is least absorbed
(a) Coated tablets
(b) Solutions
(c) Suspensions
(d) Uncoated tablets
3. Which category of drugs is evaluated for dissolution
(a) Highly diffusible
(b) Ionizable
(c) Poorly-water soluble
(d) Water-soluble
4. Which one of the initial step in drug absorption from a tablet
(a) Deaggregation
(b) Diffusion
(c) Disintegration
(d) Dissolution
5. Absorption of a drug is NOT a problem, when its solubility is about (in percent)
(a) 0.001
(b) 0.01
(c) 0.1
(d) 1.0
6. Which one of the following forms creates more difficulties regarding dissolution
(a) Amorphous form
(b) Anhydrous form
(c) Crystalline form
(d) Metastable form
7. Which one of the drugs below is expected to have the greatest dissolution
(a) Ascorbic acid
(b) Aspirin
(c) Griseofulvin
(d) Methylprednisolone
8. Which one of the following excipients enhances the dissolution of a hydrophobic drug
(a) Gum acacia
(b) Ethylcellulose
(c) Lactose
(d) Magnesium stearate
9. For in vitro–in vivo correlations, which one of the following parameters is extensively used
(a) Mean amount of drug dissolved
(b) Per cent of drug dissolved
(c) Rate of dissolution
(d) Time required for maximum dissolution
10. In dissolution experiments, which one of the following coated basket is preferred, when the acid medium is used
(a) Chrome
(b) Gold
(c) Teflon
(d) Stainless steel
ANSWER KEY
| 1-c | 2-a | 3-c | 4-c | 5-d | 6-c | 7-a | 8-c | 9-b | 10-b |
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