DISTRIBUTION OF DRUGS GPAT MCQs Part – 2

TOP 10 MCQ

1. Match the following concept in List I with parameters in List II (GPAT-2023 Shift-I)
List I (Concept)                                                 List II (Parameters)
Volume of distribution                         [P] Measure volume of real physiological plasma
Evans blue                                                [Q] Human serum albumin
3.5–5.5%                                                    [R] Volume of blood
Metallothionein                                      [S] Ratio of body drug content to plasma concentration
                                                                     [T] Protein present in kidney to bind metal
Options
(a) 1-P, 2-Q, 3-R, 4-S
(b) 1-P, 2-S, 3-R, 4-Q
(c) 1-S, 2-P, 3-Q, 4-T
(d) 1-R, 2-Q, 3-S, 4-T

2. Which of the following characteristics is most likely to be associated with a high apparent volume of distribution? (GPAT-2023 Shift-II)
(a) Penetration across the blood brain and blood testis barriers
(b) Extensive binding to plasma protein
(c) Extensive binding to tissue constituents
(d) Distribution into total body water

3. The intracellular fluid volume including those of blood cells is approximately (GPAT-2022)
(a) 7 L
(b) 17 L
(c) 27 L
(d) 37 L

4. Distribution is perfusion rate limited in case of (GPAT-2021)
(a) Ionic
(b) Lipophilic
(c) Polar
(d) Water soluble

5. Volume of blood that flows per unit time per unit volume of tissue is (GPAT-2019)
(a) Residence time
(b) Elimination rate
(c) Gastric emptying rate
(d) Perfusion rate

6. Apparent volume of distribution will be highest in case of the drug with % plasma protein binding (GPAT-2017)
(a) 10
(b) 89
(c) 50
(d) 68

7. Concentration of drug in blood is 40 mg/ml, dose of the drug is 200 mg, assuming minimal elimination Vd will be (GPAT-2015)
(a) 5 litre
(b) 0.5 litre
(c) 2.5 litre
(d) 3 litre

8. Which is used as a marker to determine total body water volume (GPAT-2014)
(a) Antipyrine
(b) Mannitol
(c) Evans blue
(d) Raffinose

9. Which marker is used for measuring the volume of plasma (GPAT-2013)
(a) Deuterium oxide
(b) Mannitol
(c) Evans blue
(d) Inulin

10. In a pharmacokinetic model depicted in the following scheme, what is the half-life of the drug if the apparent volume of distribution of the drug is 25 L (GPAT-2012)
Options
(a) 1.7 hrs
(b) 2 hrs
(c) 4 hrs
(d) 3 hrs

ANSWER KEY