DIURETICS
TOP 10 MCQ
1. Identify the diuretic which causes hyperuricemia, tend to raise serum calcium and also causes magnesium depletion [GPAT-2020]
(a) Acetazolamide
(b) Furosemide
(c) Mannitol
(d) Chlorothiazide
2. Which one of the following is NOT the property of osmotic diuretics [GPAT-2020]
(a) Undergo limited reabsorption by the renal tubule
(b) Are relatively inert pharmacologically
(c) They inhibit carbonic anhydrase
(d) Freely filtered at the glomerulus
3. Which of the following is TRUE Excessive use of diuretics can lead to [GPAT-2019]
(a) Hypervolemic shock
(b) Neurogenic shock
(c) Hypovolemic shock
(d) Cardiogenic shock
4. The following is NOT TRUE for Furosemide [GPAT-2018]
(a) Causes hypokalemia
(b) Causes hypouricemia
(c) Causes hypomagnesemia
(d) Acts by inhibiting sodium reabsorption
5. What is the normal glomerular filtration rate [GPAT-2016]
(a) 120 ml/min
(b) 140 ml/min
(c) 240 ml/min
(d) 120 ml/hour
6. Mannitol is NOT used in [GPAT-2013]
(a) Acute renal failure
(b) Pulmonary edema
(c) Cerebral edema
(d) All of these
7. Measurement of inulin renal clearance is a measure for [GPAT-2010]
(a) Effective renal blood flow
(b) Renal drug excretion rate
(c) Active renal secretion
(d) Glomerular filtration rate
8. For the following drugs, specific mechanism of action is given in [P] to [S]. Match them [GATE-1999]
Drugs
Spironolactone
Acetazolamide
Mechanism of action
[P] Non competitively inhibit the enzyme carbonic anhydrase
[Q] Inhibit the transport of Na and Cl in loop of Henle
[R] Competitive inhibitor of aldosterone at the receptors in distal tubule
[S] Direct inhibition of Na and Cl reabsorption at proximal portion
(a) 1-[Q], 2-[S]
(b) 1-[P], 2-[Q]
(c) 1-[R], 2-[P]
(d) 1-[P], 2-[S]
9. Identify one of the Carbonic Anhydrase inhibitors that inhibit only luminal carbonic anhydrase enzyme [GATE-1998]
(a) Methazolamide
(b) Acetazolamide
(c) Dichlorphenamide
(d) Benzylamide
10. The drugs [P] to [T] are used as diuretics. Match them to their classes [GATE-1993]
Class                                             Drugs
Osmotic diuretic                                 [P] Spironolactone
Loop diuretic                                    [Q] Isosorbide
Potassium sparing diuretic                       [R] Mersalyl Theophylline
Organomercurial diuretic                         [S] Furosemide
                                                 [T] Probenecid
(a) 1-[Q], 2-[P], 3-[S], 4-[R]
(b) 1-[Q], 2-[S], 3-[P], 4-[R]
(c) 1-[R], 2-[Q], 3-[P], 4-[S]
(d) 1-[P], 2-[S], 3-[R], 4-[Q]
ANSWER KEY
| 1-d | 2-c | 3-c | 4-b | 5-a | 6-b | 7-d | 8-c | 9-b | 10-b |
|
|
|
