EXCRETION OF DRUGS
TOP 10 MCQ
1. When the renal clearance (ml/min) is less than 130, which statement is true [GPAT-2016]
(a) Drug filtered and reabsorbed completely
(b) Drug filtered and reabsorbed partially
(c) Drug is filtered as well as secreted actively
(d) Clearance equal to renal plasma flow rate
2. If a basic drug is reabsorbed significantly from kidney which of the following statement will be correct [GPAT-2015]
(a) Its renal clearance increases in basic urine
(b) Its renal clearance decreases in basic urine
(c) Its renal clearance increases in acidic urine
(d) Its renal clearance decreases in acidic urine
3. Creatinine clearance is used as a measurement of [GATE-1999, GPAT-2015]
(a) Passive renal absorption
(b) Glomerular filtration rate
(c) Renal excretion rate
(d) All of these
4. What is the renal clearance of a substance, if its concentration in plasma is 10 mg, concentration in urine 0.02 ml/mg and urine flow is 2 ml/min [GPAT-2014]
(a) 0.02 ml/min
(b) 0.2 ml/min
(c) 2 ml/min
(d) 20 ml/min
5. Fluctuations occurs in rate of excretion method; these can be minimized by [GPAT-2014]
(a) Wagner-Nelson method
(b) Sigma-minus method
(c) Loo-Riegelman method
(d) Method of residuals
6. Which is used as a marker to determine total body water volume [GPAT-2014]
(a) Antipyrine
(b) Mannitol
(c) Evans blue
(d) Raffinose
7. The biological half-life of procaine in patient was 35 minutes and its volume of distribution was estimated to be 60 L. The total clearance rate of procaine is [GPAT-2013]
(a) 1.18 L/min
(b) 0.115 L/min
(c) 11.51 L/min
(d) 5.57 L/min
8. If a drug has a very small volume of distribution (V), it is likely that this drug [GATE-1998]
(a) Has a short biological life
(b) Does not accumulate in various tissues and organs
(c) Not bioavailable
(d) Will not be effective
9. pH of a buffer system can be calculated by using [GATE-1991, GATE-1992]
(a) pH partition theory
(b) Noyes-Whitney law
(c) Henderson-Hasselbalch equation
(d) None of these
10. For a certain drug, the bile flow rate is 0.7 ml/min, the biliary drug concentration is 2 g/ml and the plasma drug concentration is 0.8 g/ml. What will be the clearance?
(a) 1.50 ml/min
(b) 1.75 ml/min
(c) 2.75 ml/min
(d) 3 ml/min
ANSWER KEY
| 1-b | 2-b | 3-b | 4-d | 5-b | 6-a | 7-a | 8-b | 9-c | 10-b |
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