HISTAMINE AND ANTIHISTAMINE
TOP 10 MCQ
1. Following is an example of preformed and not lipid derived mast cell mediator of inflammatory process [GPAT-2014, 2024]
(a) LTC₄
(b) PGD₂
(c) PAF
(d) Histamine
2. The histamine is formed from histidine by [GPAT-2014, 2024]
(a) Methylation
(b) Decarboxylation
(c) Acetylation
(d) Esterification
3. “Wheal and flare” reaction is characteristic reaction associated with identification of [GPAT-2021]
(a) Type-1 hypersensitivity reaction
(b) Type-2 hypersensitivity reaction
(c) Type-3 hypersensitivity reaction
(d) Type-4 hypersensitivity reaction
4. Histamine concentration is highest in [GPAT-2018]
(a) Beta cells
(b) Mast cells
(c) Lymphocytes
(d) Adipocytes
5. All of the following are anticholinergic uses of promethazine except
(a) Motion sickness
(b) Cough
(c) Paresthetic medication
(d) Angioedema
6. Histamine in the presence of diamine oxidase forms
(a) LTC
(b) PGD₂
(c) PAF
(d) Imidazole acetic acid
7. The histamine on ______ forms N-methyl-histamine
(a) Methylation
(b) Decarboxylation
(c) Acetylation
(d) Esterification
8. The following drug is withdrawn from the market due to torsade de pointes [GPAT-2010]
(a) Chlorpromazine
(b) Astemizole
(c) Haloperidol
(d) Domperidone
9. The following receptor are associated with drug mentioned. Match them [GATE-2000]
H₁ receptor
5-HT₃ receptor
[P] Ketanserin
[Q] Cimetidine
[R] Diphenhydramine
[S] Ondansetron
(a) 1-[Q], 2-[S]
(b) 1-[R], 2-[S]
(c) 1-[R], 2-[P]
(d) 1-[P], 2-[Q]
10. Which is not a 2nd generation antihistaminic agent
(a) Cetirizine
(b) Cyclizine
(c) Loratadine
(d) Fexofenadine
ANSWER KEY
| 1-d | 2-b | 3-a | 4-b | 5-d | 6-d | 7-a | 8-b | 9-b | 10-b |
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