HYPOLIPIDEMIC DRUGS
TOP 10 MCQ
1. The enzyme HMG-CoA reductase is involved in the pathogenesis of [GPAT-2018]
(a) Atherosclerosis
(b) Renal failure
(c) Alzheimer disease
(d) Parkinson disease
2. Increased serum levels of which one of the followings may be associated with decreased risk of atherosclerosis [GPAT-2012]
(a) VLDL
(b) LDL
(c) HDL
(d) Total Cholesterol
3. Rhabdomyolysis is the side effect associated with which of the following classes of drugs [GPAT-2011]
(a) ACE inhibitors
(b) Statins
(c) Calcium channel blockers
(d) Sodium channel blockers
4. Which of the following is the most effective monotherapy for raising HDL cholesterol [GPAT-2013]
(a) Statins
(b) Niacin
(c) Ezetimibe
(d) Omega-3 fatty acids
5. A metabolite obtained from Aspergillus terreus that can bind very tightly to HMG-CoA reductase enzyme is [GPAT-2010]
(a) Fluvastatin
(b) Cerivastatin
(c) Lovastatin
(d) Somatostatin
6. Effect of fibrates on blood lipids are mediated by [GATE-2008]
(a) Inhibiting both synthesis and esterification of fatty acids
(b) Their interaction with peroxisome proliferator-activated receptors (PPARs)
(c) Reducing the conversion of HMG-CoA to mevalonate
(d) Sequestering bile acids
7. A patient receiving Digoxin for CCF is found to have elevated serum cholesterol. Which hypolipidemic agent should not be prescribed [GATE-2005]
(a) Clofibrate
(b) Cholestyramine
(c) Lovastatin
(d) Niacin
8. Simvastatin belongs to [GATE-2004]
(a) HMG-CoA reductase inhibitor type of antilipidemic agents
(b) HMG-CoA reductase inhibitor type of anticoagulant agents
(c) Fibrate type of anticoagulant agents
(d) Fibrate type of antilipidemic agents
9. Ezetimibe acts by
(a) Enhancing excretion of bile acids
(b) Decreasing absorption of cholesterol
(c) Inhibiting HMG-CoA reductase
(d) Inhibiting intracellular lipase
10. True about fibrates is all except
(a) Drug of choice for Type III hyperlipoproteinemia and severe hypertriglyceremia
(b) Activate PPAR to stimulate LPL
(c) Absorbed good on empty stomach and absorption is delayed by fatty meals
(d) Side effects are rash, urticaria, myalgia and impotence
ANSWER KEY
| 1-a | 2-c | 3-b | 4-b | 5-c | 6-b | 7-c | 8-a | 9-b | 10-c |
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