MACROLIDE, LINCOSAMIDE, GLYCOPEPTIDE AND OTHER ANTIBACTERIAL ANTIBIOTICS
TOP 10 MCQ
1. Identify the one rational combination which has clinical benefit [GPAT-2010]
(a) Norfloxacin – Metronidazole
(b) Alprazolam – Paracetamol
(c) Cisapride – Omeprazole
(d) Amoxicillin – Clavulanic acid
2. Tacrolimus is a macrolide antibiotic, which bears the following attributes [GATE-2007]
[P] Produced from streptomyces hygroscopicus and is chemically related to cyclosporine
[Q] Binds with cytoplasmic peptidyl-propyl-isomerase and can be useful in liver and kidney transplant
[R] Produced from streptomyces tsukubaensis and is chemically unrelated to cyclosporine
[S] An inhibitor of pyrimidine synthesis, used in rheumatoid arthritis
(a) [P], [Q]
(b) [P], [S]
(c) [Q], [R]
(d) [Q], [S]
3. A macrolide antibiotic used as a powerful immunosuppressive agent is [GATE-2005]
(a) Erythromycin
(b) Azithromycin
(c) Tacrolimus
(d) Clarithromycin
4. Azithromycin is clinically administered once daily as compared to Erythromycin which is administered every 6 hours because Azithromycin [GATE-2004]
(a) Penetrates into most tissue and is released very slowly
(b) Has a methylated nitrogen in its lactone ring which renders it much more potent than Erythromycin
(c) Is a very potent antibiotic but not tolerated well in the gastrointestinal tract
(d) Is usually presented in a sustained release dosage
5. Erythromycin is an antibiotic. It belongs to the class of [GATE-1991]
(a) β-Lactam
(b) Aminoglycoside
(c) Macrolide
(d) Peptide
6. Clindamycin acts by inhibiting
(a) Cell wall synthesis
(b) Protein synthesis
(c) Cell membrane synthesis
(d) Glucose utilization
7. Which of the following is a glycopeptide antibiotic
(a) Vancomycin
(b) Penicillin
(c) Clindamycin
(d) Tetracycline
8. Red man syndrome is due to
(a) Vancomycin
(b) Polymyxin
(c) Rifampicin
(d) Teicoplanin
9. Oral Vancomycin can be used for treatment of
(a) Hepatic encephalopathy
(b) Pseudomembranous colitis
(c) Staphylococcal food poisoning
(d) None of the above
10. Which of the following antibacterial causes both ototoxicity and nephrotoxicity
(a) Methicillin
(b) Vancomycin
(c) Clindamycin
(d) Azithromycin
ANSWER KEY
| 1-d | 2-c | 3-c | 4-b | 5-c | 6-b | 7-a | 8-a | 9-b | 10-b |
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