MONOPHASIC LIQUIDS DOSAGE FORM GPAT MCQs Part – 2

TOP 10 MCQ

1. An elixir contains 47% v/v alcohol, what is the proof spirit according to USP [GPAT–2024]
(a) 91%
(b) 82%
(c) 70%
(d) 63%

2. Which of the following is not a method for solubility enhancement [GPAT–2024]
(a) Co-solvency
(b) Salt formation
(c) Hydrotropy
(d) Crystallization

3. Clear, sweetened hydroalcoholic solutions intended for oral use, usually flavored to enhance their palatability are called [GPAT–2023 SHIFT-I, II]
(a) Aromatic waters
(b) Elixirs
(c) Syrups
(d) Tinctures

4. Indicate which of the following molecular characteristics will be expected to increase the solubility of a simple solute in an aqueous solution [GPAT–2023 SHIFT-I]
(a) A high melting point
(b) The presence of polar group
(c) A high molecular surface area
(d) A high boiling point

5. Select correct option for miscible solvents [GPAT–2022]
[A] Water and alcohol
[B] Acetone and alcohol
[C] Water and benzene
[D] Carbon tetrachloride and benzene
Choose the correct answer from the options given below:
(a) A and B only
(b) A, B and C only
(c) A, B and D only
(d) A and D onl

6. The phenomenon of increasing the solubility of weak electrolytes and non-polar molecules by the addition of water-miscible solvent in which the drug has good solubility is called [GPAT-2002, GPAT-2021]
(a) Complexation
(b) Co-solvency
(c) Solubilization
(d) Hydrotropy

7. In case of solvates the following are examples of Class I residual solvents that have been classified by the ICH [GPAT-2021]
(a) Benzene, carbon tetrachloride and 1,2-dichloroethane
(b) Acetonitrile, cyclohexane and toluene
(c) Methanol and N,N-dimethylacetamide
(d) Acetic acid, acetone and ethanol

8. As per I.P., if the solubility range of a solute is 30 to 100 parts, it will be [GPAT-2017]
(a) Soluble
(b) Freely soluble
(c) Sparingly soluble
(d) Slightly soluble

9. The number of glucopyranose units in the structure of alpha-cyclodextrins are [GPAT-2017]
(a) 8
(b) 9
(c) 7
(d) 6

10. Which of the following equation is correct to determine the pH of weak base [GPAT-2016]
(a) pH = pKa − log (ionized drug conc./unionized drug conc.)
(b) pH = pKa + log (ionized drug conc./unionized drug conc.)
(c) pH = pKa − log (unionized drug conc./ionized drug conc.)
(d) pH = pKa + antilog (unionized drug conc./ionized drug conc.)

ANSWER KEY