NON-LINEAR PHARMACOKINETICS
TOP 10 MCQ
1. Non-linear pharmacokinetics can be expected due to [GPAT-2011]
[P] Enzyme induction
[Q] Active secretion
Choose the correct answer
(a) Both [P] and [Q] are true
(b) [P] is true, [Q] is false
(c) [Q] is true, [P] is false
(d) Both [P] and [Q] are false
2. The characteristic of non-linear pharmacokinetics includes [GPAT-2010]
(a) Area under the curve is proportional to the dose
(b) Elimination half-life remains constant
(c) Area under the curve is not proportional to the dose
(d) Amount of drug excreted through remains constant
3. Which one of these are correct Michaelis-Menten equation
(a) −dC/dt = Vmax C / (Km + C)
(b) dC/dt = Vmax C / (Km + C)
(c) −dC/dt = Vmax C / Km
(d) −dC/dt = Km + C / Vmax C
4. Clearance of a drug with high ER is greatly increased due to
(a) Drug metabolism
(b) Drug excretion
(c) Saturation of binding sites
(d) Low absorption
5. Kinetics of capacity-limited or saturable process is best described by
(a) Michaelis-Menten equation
(b) Fick’s law
(c) Hanes-Woolf plot
(d) Lineweaver-Burke plot
6. Causes of nonlinearity is
(a) Drug absorption
(b) Drug distribution
(c) Drug metabolism
(d) All of the above
7. The parameter Km and Vmax can be assessed from
(a) Plasma concentration-time data
(b) Clearance data
(c) Distribution data
(d) Extraction data
8. In non-linear pharmacokinetics, the parameter clearance:
(a) Remains constant
(b) Increases with increasing drug concentration
(c) Decreases with increasing drug concentration
(d) Is independent of the dose administered
9. Pharmacokinetics parameters change as per ______ of dose administered
(a) Size
(b) Route
(c) Both of the above
(d) None of the above
10. In ______ Pharmacokinetic parameters for a drug can change with change in dose
(a) Linear Pharmacokinetics
(b) Non-linear Pharmacokinetics
(c) Both of the above
(d) None of the above
ANSWER KEY
| 1-a | 2-c | 3-a | 4-c | 5-a | 6-d | 7-a | 8-c | 9-a | 10-b |
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