NSAIDs
TOP 10 MCQ
1. Choose the most appropriate statement for the peptic ulcer disease caused by NSAIDs [GPAT-2023 SHIFT-II]
(a) Hâ‚‚ antagonists offer rapid healing
(b) Hâ‚‚ antagonists offer rapid healing provided the NSAID is discontinued
(c) Proton pump inhibitor to be given only if the NSAID is discontinued
(d) NSAIDs are strictly contraindicated with proton pump inhibitors
2. Which among the following is NOT used as NSAIDs [GPAT-2023 SHIFT-III]
(a) Indomethacin extended release 75 mg
(b) Aspirin 75 mg
(c) Naproxen 500 mg
(d) Mefenamic acid 500 mg
3. A 3-year-old child presented to OPD with the symptoms of influenza. Ask if aspirin is contraindicated in the patient because of increased risk of [GPAT-2021]
(a) Gastric bleeding
(b) Thrombocytopenia
(c) Fanconi syndrome
(d) Reye’s syndrome
4. Meloxicam belongs to which class of Non-steroidal Anti-inflammatory Drugs (NSAIDs) [GPAT-2020]
(a) Preferential COX-1 inhibitor
(b) Selective COX-1 inhibitor
(c) Preferential COX-2 inhibitor
(d) Selective COX-2 inhibitor
5. Hepatic toxicity in paracetamol is caused due to an active metabolite. It is [GPAT-2013]
(a) N-acetyl-p-benzoquinonimine (NAPQI)
(b) N-acetyl-p-benzoquinone (NAPQ)
(c) N-acetyl-p-benzoquinonime (NAPQI)
(d) N-alkyl-p-benzoquinonimine (NAPQI)
6. N-acetyl cysteine is beneficial in acute paracetamol poisoning because [GPAT-2013]
(a) It reacts with paracetamol to form a nontoxic complex
(b) It inhibits the generation of the toxic metabolite of paracetamol
(c) It is a free radical scavenger
(d) It replenishes hepatic glutathione stores which in turn binds the toxic metabolite of paracetamol
7. Low dose aspirin acts as anti-platelet aggregating agent by which one of the following mechanisms. Find the correct answer [GPAT-2012]
(a) It acts as suicide substrate for COX-1 enzyme present in platelets
(b) It acts as translational state analogue for COX-2 enzyme present in the platelets
(c) It acts as a reversible inhibitor of lipoxygenase present in the platelets
(d) It acts as an affinity label of oxidoreductase present in the platelets
8. Which of the following non-opioid analgesic is a prodrug [GPAT-2010]
(a) Piroxicam
(b) Celecoxib
(c) Nabumetone
(d) Ketorolac
9. A young patient complains that he gets severe shortness of breath whenever he takes aspirin for headache. Increased levels of a substance responsible for aspirin hypersensitivity is [GATE-2009]
(a) Prednisone
(b) Prostacyclin
(c) Ibuprofen
(d) Leukotriene LTCâ‚„
10. Co-administration of NSAIDs with warfarin may often lead to [GATE-2008]
(a) Antagonistic interaction
(b) Interaction due to change in drug transport
(c) Interaction due to disturbances in electrolyte balance
(d) Additive or synergistic interaction
ANSWER KEY
| 1-b | 2-b | 3-d | 4-a | 5-b | 6-d | 7-a | 8-c | 9-d | 10-d |
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