OPIOID ANALGESICS AND ANTAGONISTS
TOP 10 MCQ
1. Morphine does not cause [GPAT-1998, 2014, 2024]
(a) Constriction of pupil
(b) Respiratory depression
(c) CNS depression
(d) Diarrhoea
2. Which one of the following is NOT an endogenous opioid peptide [GPAT-2021]
(a) Met enkephalin
(b) Leu enkephalin
(c) Dynorphin
(d) Betalipotropin
3. Which one is NOT an opioid receptor [GPAT-2020]
(a) Gamma
(b) Kappa
(c) Mu
(d) Delta
4. The decreasing order of Narcotic action is [GPAT-2015]
(a) Morphine, Codeine, Papaverine, Narcotine, Thebaine
(b) Morphine, Codeine, Thebaine, Papaverine, Narcotine
(c) Morphine, Papaverine, Codeine, Narcotine, Thebaine
(d) Morphine, Papaverine, Narcotine, Codeine, Thebaine
5. Which of the following statements correctly describes the pharmacological management of opioid dependence and withdrawal?
(a) Methadone is used during de-addiction to block euphoric effects of opioids
(b) Naltrexone is used to prevent relapse by blocking μ receptors and euphoric effects
(c) Sudden withdrawal is safe in long-term opioid addiction if accompanied by β-blockers
(d) Clonidine is used to maintain opioid de-addiction and prevent relapse
Following are some opioid analgesics [GPAT-2012]
[P] Morphine
[Q] Pethidine
[R] Pentazocine
[S] Fentanyl
6. Choose the correct order of respiratory depressant property of these agents
(a) P > Q > R > S
(b) Q > P > R > S
(c) R > P > Q > S
(d) S > P > Q > R
7. The chemical behavior of Morphine alkaloid is [GPAT-2010]
(a) Acidic
(b) Basic
(c) Neutral
(d) Amphoteric
8. One of the following opioid peptides is released from proopiomelanocortin (POMC) [GATE-2001]
(a) Somatostatin
(b) Beta-endorphin
(c) Leu-enkephalin
(d) Dynorphin
9. One of the following actions of opioid analgesic is mediated via kappa receptors [GATE-2001]
(a) Cerebrovascular dilation
(b) Euphoria
(c) Spinal analgesia
(d) Physical dependence
10. Morphine undergoes microsomal oxidation by [GATE-2001]
(a) N-dealkylation
(b) Aromatic hydroxylation
(c) Oxidative deamination
(d) O-dealkylation
ANSWER KEY
| 1-d | 2-d | 3-a | 4-c | 5-b | 6-d | 7-b | 8-d | 9-c | 10-ab |
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