PHARMACODYNAMICS
TOP 10 MCQ
1. G-protein receptors are [GPAT-2014, 2024]
(a) Monomeric
(b) Dimeric
(c) Trimeric
(d) Tetrameric
2. Which of the following hypolipidemic drugs act via a GPCR [GPAT-2023 SHIFT-I]
(a) Nicotinic acid
(b) Fenofibrate
(c) Atorvastatin
(d) Ezetimibe
3. Receptor for which no endogenous mediator or ligand is at present known as [GPAT-2015]
(a) Silent receptors
(b) Spare receptors
(c) Orphan receptors
(d) False receptors
4. A competitive antagonist is a substance that [GPAT-2015]
[P] Interacts with receptors and produces submaximal effect
[Q] Binds to the same receptor site and progressively inhibits the agonist response
[R] Binds to the nonspecific sites of tissue
(a) [P] true, [Q] & [R] false
(b) [P] & [Q] true, [R] false
(c) [Q] true, [P] & [R] false
(d) [Q] & [R] true, [P] false
5. The increase in concentration of second messengers (cAMP, cGMP, Ca²⁺ etc.) leads to [GPAT-2013]
(a) Inhibition of intracellular protein kinases and protein phosphorylation
(b) Protein kinases activation and protein phosphorylation
(c) Blocking of interaction between a receptor and an effector
(d) Antagonism with endogenous ligands
6. Which one of the following is a FALSE statement for competitive antagonists [GPAT-2012]
(a) They have an affinity for the agonist binding site on receptor
(b) They have no intrinsic activity
(c) They cause parallel rightward shift of the control dose response curve
(d) Maximum response of the agonist cannot be achieved in their presence by increasing the concentration of the agonist
7. Which one of the following receptor is NOT a ligand-gated ion channel receptor [GPAT-2012]
(a) Nicotinic receptor
(b) 5HT₃ receptor
(c) GABA receptor
(d) H₂ receptor
8. Which one of the following is NOT an example of G-protein coupled receptor [GPAT-2011]
(a) Muscarinic cholinergic receptor
(b) Alpha adrenoceptor
(c) Nicotinic cholinergic receptor
(d) Beta adrenoceptor
9. Which one of the following drugs does NOT act through G-Protein coupled receptors [GPAT-2010]
(a) Epinephrine
(b) Insulin
(c) Dopamine
(d) TSH
10. Identify the receptor which demonstrates the fastest onset of response, when stimulated [GATE-2007]
(a) Nuclear receptors
(b) Ionotropic receptors
(c) G-protein coupled receptors
(d) Insulin receptor
ANSWER KEY
| 1-c | 2-a | 3-c | 4-c | 5-b | 6-d | 7-d | 8-c | 9-b | 10-b |
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