PHARMACOKINETICS BASIC CONSIDERATION
TOP 10 MCQ
1. For a drug that follows first-order kinetics, the rate of elimination:
(a) Is constant irrespective of plasma concentration
(b) Increases with an increase in plasma concentration
(c) Decreases with a decrease in plasma concentration
(d) Both (b) and (c)
2. Which of the following pharmacokinetics parameter is useful in representing the rate and extent of absorption of a drug [GPAT-2013]
(a) Cmax
(b) Clearance
(c) tmax
(d) Area under the curve
3. What will be the approximate Tmax of a drug exhibiting Ka of 2 hr⁻¹ and K of 0.2 hr⁻¹ [GPAT-2012]
(a) 1.2 hr
(b) 2.4 hr
(c) 4.8 h
(d) 2.0 hr
4. What will be the time required for a drug exhibiting first order rate constant of 4.6/hr to be degraded from initial concentration of 100 mg/ml to 10 mg/ml [GPAT-2011]
(a) 2 hr
(b) 4 hr
(c) 9 h
(d) 0.5 hr
COMMON DATA FOR QUESTION (185-186)
A solution of the drug was freshly prepared at a concentration of 600 mg/ml. After 30 days of storage at 25°C, the drug concentration in the
solution was found to be 150 mg/ml.
The drug can be assumed to undergo zero-order kinetics.
5. The rate constant is [GATE-2006]
(a) 15 mg/ml/day
(b) 1.5 mg/ml/day
(c) 0.15 mg/ml/day
(d) 7.5 mg/ml/day
6. Half-life of the drug solution under these condition is [GATE-2006]
(a) 2 days
(b) 20 days
(c) 10 days
(d) 100 days
COMMON DATA FOR QUESTION (187-189)
A drug solution has an initial potency of 300 mg/10 ml.
When stored in a refrigerator for 30 days, its potency was found to be 100 mg/10 ml.
7. The rate constant, assuming that the drug solution undergoes first order kinetics, is [GATE-2005]
(a) 0.0366 day⁻¹
(b) 0.0074 day⁻
(c) 0.0174 day⁻¹
(d) 0.0506 day⁻¹
8. Half-life of the drug solution, under this condition is [GATE-2005]
(a) 9.4 days
(b) 19 days
(c) 47 days
(d) 4.7 days
9. The half-life for a zero-order reaction is calculated using [GATE-2005]
(a) −0.693/k
(b) 2.303/k
(c) 1/ak
(d) a/2k
10. Which model provide concise means of expressing mathematically or quantitatively, the time course of drug throughout the body and compute meaningful pharmacokinetic parameters
(a) Toxicokinetic model
(b) Pharmacokinetic model
(c) Population model
(d) Pharmacodynamic model
ANSWER KEY
| 1-d | 2-d | 3-a | 4-d | 5-a | 6-b | 7-a | 8-b | 9-d | 10-b |
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