PREFORMULATION
TOP 10 MCQ
1. Which of the following molecular properties can be determined by Thermogravimetric Analysis [GPAT–2023 SHIFT-I]
(a) Solubility
(b) Hygroscopicity
(c) Colour stability
(d) Hydrolysis
2. A crystalline powder that contains water of crystallization or hydration; this water can be liberated either during manipulations or on exposure to a low-humidity environment; the powder becomes sticky and pasty or may even melt. Such a powder is called [GPAT–2023 SHIFT-I]
(a) Eutectic
(b) Hygroscopic
(c) Deliquescent
(d) Efflorescent
3. Dynamic Vapour Sorption (DVS) isotherm is a plot of A versus B [GPAT–2021]
(a) A – Crystallization Peak Energy (J/g), B – Percentage Relative Humidity
(b) A – Percentage Change in Mass, B – Percentage Relative Humidity
(c) A – Crystallization Peak Energy (J/g), B – Percentage Change in Mass
(d) A – Crystallization Peak Energy (J/g), B – Amorphous Content
4. As per European Pharmacopoeia technical guide, substance stored at 25°C for 24 hours at 80% RH is called very hygroscopic when increase in weight is [GPAT–2020]
(a) 0.2% w/w and <15% w/w
(b) >0.2% w/w and <20% w/w
(c) >15% w/w
(d) 0.2% w/w and <2% w/w
5. The polymorphs exhibit the following different properties EXCEPT [GPAT–2020]
(a) X-ray crystal and diffraction patterns
(b) Melting points
(c) Solubilities
(d) Chemical structures
6. While studying solid-state physicochemical properties, the packing property of drug include [GPAT–2020]
(a) Heat capacity
(b) Solubility
(c) Refractive index
(d) Entropy
7. Which polymorphic form of a drug candidate has highest melting point [GPAT–2019]
(a) Unstable
(b) Metastable
(c) Hydrates
(d) Stable
8. In preformulation study polymorphs can be detected by [GPAT–2019]
(a) Counter current chromatography
(b) Refractometry
(c) High performance liquid chromatography
(d) Differential scanning calorimetry
9. Phase solubility analysis curve is not a good tool for [GPAT–2019]
(a) Complex formation
(b) Bioavailability determination
(c) Polymorph detection
(d) Impurity detection
10. Which of the following techniques is not useful to detect polymorphs [GPAT–2017]
(a) DSC
(b) HPLC
(c) PXRD
(d) Melting point determination
ANSWER KEY
| 1-b | 2-d | 3-b | 4-c | 5-d | 6-c | 7-d | 8-d | 9-b | 10-b |
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