PROSTAGLANDINS, LEUKOTRIENES (EICOSANOIDS) AND PLATELET ACTIVATING FACTOR
TOP 10 MCQ
1. Compounds that have both TXA₂ synthase inhibition as well as TXA₂ receptor blocking activity [GPAT-2024]
(a) Dazoxiben
(b) Ridogrel
(c) Moclobemide
(d) Aspirin
2. Prostaglandin analogues have therapeutic utility in the following EXCEPT [GPAT-2021]
(a) Impotence
(b) Peripheral vascular disease
(c) Palliative treatment of patent ductus arteriosus
(d) Pulmonary hypertension
3. Misoprostol has a cytoprotective action on gastrointestinal mucosa because of one of the following actions. Identify this [GPAT-2012]
(a) It enhances secretion of mucus and bicarbonate ion
(b) It neutralizes hydrochloric acid in stomach
(c) It antagonizes nonsteroidal anti-inflammatory drugs
(d) It is bactericidal to H. pylori
4. Which of the following is/are example of eicosanoid
(a) Prostaglandin
(b) Prostacyclin
(c) Thromboxane
(d) All of the above
5. Following are uses of prostaglandins EXCEPT
(a) First trimester of pregnancy termination
(b) Cervical ripening during labour
(c) Postpartum hemorrhage
(d) Dysmenorrhoea
6. Which of the prostaglandin analogue is used in wide angle glaucoma
(a) PGE₁
(b) PGF₂α
(c) PGE₂
(d) PGD₂
7. Which of the following drugs inhibit an enzyme in the prostaglandin synthesis
(a) Alteplase
(b) Aspirin
(c) Aprotinin
(d) Aminocaproic acid
8. Which of the prostaglandin analogue is used in NSAID induced gastritis
(a) PGE₁
(b) PGF₂α
(c) PGE₂
(d) PGD₂
9. Misoprostol is a
(a) Prostaglandin E₁ analogue
(b) Prostaglandin E₂ analogue
(c) Prostaglandin antagonist
(d) Antiprogestin
10. Therapeutic uses of prostaglandin E₁ include all of the following EXCEPT
(a) Medical termination of pregnancy
(b) Impotence
(c) Primary pulmonary hypertension
(d) Maintenance of patent ductus arteriosus
ANSWER KEY
| 1-b | 2-c | 3-a | 4-d | 5-d | 6-b | 7-b | 8-a | 9-a | 10-c |
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