PROTEIN BINDING OF DRUGS GPAT MCQs Part – 3

TOP 10 MCQ

1. P-gp (p-glycoprotein) is highly expressed on the (GPAT-2011)
(a) Lungs
(b) Pancreas
(c) Superficial columnar epithelial cells of ileum and colon
(d) Heart

2. The majority of drugs that least binded to ant vascular tissue is (GPAT-2011)
(a) Liver
(b) Muscle
(c) Lungs
(d) Kidneys

3. Molecular weight of human serum albumin is [GPAT-2020]
(a) 64,000
(b) 64,500
(c) 65,000
(d) 65,500

4. The following is/are used to determine the amount of drug bound to a protein [GPAT-2019]
(a) Equilibrium dialysis
(b) Solubility
(c) pH titration
(d) Distribution method

5. Apparent volume of distribution will be highest for following drugs
(a) Chloroquine
(b) Diazepam
(c) Ephedrine
(d) Captopril

6. There are some statements related to the protein binding of drugs as given below [GPAT-2012]
[P] Protein binding decreases the free drug concentration in the system
[Q] Protein binding to plasma albumin is an irreversible process
[R] Drugs with a low lipophilicity have a high degree of protein binding
[S] Protein binding of one drug can be affected by the presence of other drug
Choose the correct combination of statements
(a) P & Q are true while R & S are false
(b) Q & R are true while P & S are false
(c) R & S are true while P & Q are false
(d) P & S are true while Q & R are false

7. Which is NOT applicable to protein binding [GPAT 2011]
(a) Klotz reciprocal plot
(b) Sandberg modified equation
(c) Blanchard equation
(d) Detli plot

8. When the drug bind to an extra cellular protein but the binding does not usually elicit a pharmacological response. This type of binding is called
(a) Intracellular binding
(b) Extracellular binding
(c) Both (a) and (b)
(d) None of the above

9. Protein–drug binding generally involves
(a) Hydrogen bonds
(b) Hydrophobic bonds
(c) Vander Waals forces
(d) All of the above

10. The order of binding of drugs to various plasma proteins is
(a) Globulins > lipoproteins > α1-acid glycoprotein > albumin
(b) Globulins < lipoproteins < α1-acid glycoprotein < albumin
(c) Albumin < α1-acid glycoprotein < lipoproteins < globulins
(d) Albumin > α1-acid glycoprotein > lipoproteins > globulins

ANSWER KEY