SEDATIVE AND HYPNOTICS
TOP 10 MCQ
1. A drug ‘X’ is more selective for the α₁ subunit of BZD receptors. It lacks effect on slow-wave sleep, minimum residual daytime sedation, no rebound insomnia on discontinuation, low abuse potential. Which of the following can be ‘X’ [GPAT-2023 SHIFT-II]
(a) Flurazepam
(b) Flumazenil
(c) Melatonin
(d) Zolpidem
2. Which one of the following is a competitive antagonist at benzodiazepine site of GABA-receptor gated chloride channel [GPAT-2011]
(a) Muscimol
(b) Flumazenil
(c) Picrotoxin
(d) Beta-carboline (DMCM)
3. Which among the following is a structural variant of GABA and is used as a muscle relaxant [GPAT-2017]
(a) Metocurine
(b) Tybamate
(c) Baclofen
(d) Cyclobenzaprine
4. The ultra-short acting barbiturates have brief duration of action due to [GATE-2002]
(a) High degree of binding to plasma protein
(b) Low lipid solubility resulting in a minimal concentration in the brain
(c) Metabolism is slow in the liver
(d) Rapid rate of redistribution from the brain due to its high liposolubility
5. Benzodiazepines potentiate [GATE-1994]
(a) The binding of protein to nervous tissue
(b) The binding of GABA to liver
(c) The binding of GABA to receptors
(d) The binding of GABA to carbohydrates
6. All the statement mentioned below about chloral hydrate is true EXCEPT that it [GATE-1990]
(a) Produces hypnosis
(b) Produces analgesia
(c) Produce dependence
(d) Irritate gastric mucosa
7. “Agent which causes calmness without inducing sleep” is
(a) Sedatives
(b) Hypnotics
(c) Antianxiety
(d) Antiepileptics
8. Benzodiazepine mechanism of action is
(a) Hyperpolarization
(b) Increasing the opening time of chloride ions
(c) Both (a) and (b)
(d) By blocking sodium channel
9. Duration of action of flumazenil is
(a) 5 minute
(b) 10 minute
(c) 20 minute
(d) 30 minute
10. Which of the following compounds acts as a benzodiazepine antagonist
(a) Flumazenil
(b) Naloxone
(c) Furazolidone
(d) Naltrexone
ANSWER KEY
| 1-d | 2-b | 3-c | 4-d | 5-c | 6-a | 7-a | 8-c | 9-d | 10-a |
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