SEMISOLID DOSAGE FORM
TOP 10 MCQ
1. What should be the log P value for an ideal drug candidate for transdermal permeation? [GPAT 2024]
(a) Below 1
(b) 1–3
(c) 5–7
(d) Above 7
2. While preparing the following [GPAT – 2023 SHIFT – III]
Rx
Salicylic acid: 3 g
Sulfur ppt: 7 g
Lanolin: 10 g
White petrolatum: 10 g
The pharmacist should:
(a) Use a rubber spatula to weigh and levigate the salicylic acid
(b) Mix the powders using geometric dilution in a mortar
(c) Place on an ointment tile and levigate the ingredients using geometric dilution
(d) All of these
3. Which one of the following is an example of ointment prepared by trituration and containing liquids and solids [GPAT – 2023 SHIFT – II]
(a) Salicylic and Sulphur Ointment BPC
(b) Whitfield’s Ointment BPC
(c) Hamamelis Ointment BPC
(d) Resorcinol Ointment Compound BPC
4. Which of the following ointment bases is an Absorption base [GPAT – 2023 SHIFT – I]
(a) Yellow ointment, USP
(b) Hydrophilic petrolatum USP
(c) Hydrophilic ointment USP
(d) PEG ointment NF
5. Given below are two statements, one labelled as Assertion (A) and the other labelled as Reason (R) [GPAT – 2023 SHIFT – II]
Assertion (A): In case of Salicylic Acid Ointment BP Wool Alcohol Ointment made with white soft paraffin is used.
Reason (R): Wool Alcohol Ointment made with white soft paraffin is used because the medicament is colored.
Choose the correct option:
(a) Both (A) and (R) are true and (R) is the correct explanation of (A)
(b) Both (A) and (R) are true but (R) is not the correct explanation of (A)
(c) (A) is true but (R) is false
(d) (A) is false but (R) is true
6. Which of the following ointment bases is an ingredient of an absorption base [GPAT – 2021]
(a) Petrolatum
(b) Lanolin
(c) Hydrogenated castor oil
(d) Cetyl alcohol
7. Dimethyl sulfoxide acts as penetration enhancer for topical formulations by [GPAT – 2020]
(a) Increasing solubility
(b) Denaturing proteins
(c) Increasing transepidermal loss
(d) Altering solvent nature of membrane
8. Hypodermoclysis refers to which route of drug administration [GPAT – 2018]
(a) Sublingual
(b) Intradermal
(c) Subcutaneous
(d) Intravenous
9. Whitfield ointment contains which of the antifungal drug [GPAT – 2014]
(a) Itraconazole
(b) Terbinafine
(c) Benzoic acid and Salicylic acid
(d) Ketoconazole
10. Identify the incorrect match of MOA of penetration enhancer [GPAT – 2014]
(a) DMSO – Protein denaturation
(b) Pyrrolidones – Alter solvent nature of membrane
(c) Adapalene – Lipid fluidization
(d) Pyrrolidones – Increase drug solubility & thermodynamic activity
ANSWER KEY
| 1-c | 2-b | 3-d | 4-d | 5-a | 6-b | 7-c | 8-a | 9-b | 10-b |
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