SULFONAMIDES, COTRIMOXAZOLE AND QUINOLONES
TOP 10 MCQ
1. Because Trimethoprim enters many tissues, has a larger Vd than Sulfamethoxazole therefore for obtaining optional synergistic, which will be the correct dose ratio [GPAT-2014, 2024]
(a) Sulfamethoxazole 5 : Trimethoprim 1
(b) Trimethoprim 5 : Sulfamethoxazole 1
(c) Sulfamethoxazole 5 : Trimethoprim 1/5
(d) Trimethoprim 5 : Sulfamethoxazole 1/5
2. Tendon rupture or tendonitis of Achilles tendon is an adverse reaction of [GPAT-2021]
(a) Fluoroquinolones
(b) Tetracyclines
(c) Cephalosporin
(d) Aminoglycosides
3. Combaspers is combination of trimethoprim with sulfamethoxazole. Which of the following statement is CORRECT about Cotrimoxazole [GPAT-2020]
(a) Cotrimoxazole is contraindicated during pregnancy
(b) Most effective ratio of trimethoprim : sulfamethoxazole in plasma is 20 : 1
(c) Trimethoprim : sulfamethoxazole are administered in a dose ratio of 5 : 1 to achieve optimal synergistic effect
(d) Cotrimoxazole is ineffective in treating respiratory tract infections
4. The mechanism of action of Ciprofloxacin is [GPAT-2018]
(a) Inhibition of protein synthesis by interacting with 50S ribosome
(b) Inhibition of protein synthesis by interacting with 30S ribosome
(c) Inhibition of DNA synthesis by interfering with topoisomerase
(d) Inhibition of cell wall synthesis
5. Most accepted mechanism for developing bacterial resistance to Sulphonamide is [GPAT-2017]
(a) An alternative metabolic pathway for synthesis of essential metabolites
(b) An increasing capacity to metabolize the drug
(c) Increased antagonism of drug
(d) An alteration in enzyme that utilizes PABA
6. Which of the following sulfonamides is primarily used in the treatment of ulcerative colitis?
(a) Sulfadiazine
(b) Sulfasalazine
(c) Sulfisoxazole
(d) Sulfamethoxazole
7. Which one of the following statements is FALSE for fluoroquinolones [GPAT-2012]
(a) These are highly effective by oral routes
(b) These are resistant to development of resistance
(c) These are effective against those bacteria that are resistant to β-lactam and aminoglycoside antibiotics
(d) These are bactericidal with broad spectrum of activity
8. Stevens Johnson syndrome is the most common adverse effect associated with one of the following categories of drugs [GATE-2010]
(a) Sulphonamides
(b) Sulfonamides
(c) Penicillins
(d) Tetracyclines
9. The silver sulfadiazine (SILVADENE) is an effective topical antimicrobial agent in burns because of its two important attributes [GATE-2007]
[P] Broad spectrum of activity
[Q] Active against pseudomonas spp.
[R] The salt is only very slightly soluble and it does not penetrate the wall, instead it acts on the surface
[S] The salt is highly soluble and hence it is rapidly absorbed
(a) [P], [Q]
(b) [P], [S]
(c) [Q], [R]
(d) [R], [S]
10. Sulfonamides do NOT have adverse drug interaction with [GATE-2004]
(a) Oral anticoagulants
(b) Sulfonylurea hypoglycemic agent
(c) Hydantoin anticonvulsant
(d) Dihydrofolate reductase inhibitors
ANSWER KEY
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