SUPPOSITORIES
TOP 10 MCQ
1. Sarong SpA semiautomatic equipment is used for the [GPAT – 2023 SHIFT – III]
(a) Filling and packaging line for topical pharmaceutical aerosols
(b) Filling of hard gelatin capsule
(c) Production of suppositories
(d) Inserting rubber closure in vials
2. Given below are two statements, one is labelled as Assertion [A] and the other is labelled as Reason [R].
Assertion [A]: In the manufacturing of glycero-gelatin suppositories, overfilling of mould is necessary.
Reason [R]: Glycero-gelatin bases contract very little on cooling and the excess cannot be neatly removed in light of the above statements, choose
the correct answer from the options given below [GPAT – 2022]
(a) Both [A] and [R] are true and [R] is the correct explanation of [A]
(b) Both [A] and [R] are true but [R] is not the correct explanation of [A]
(c) [A] is true but [R] is false
(d) [A] is false but [R] is true
3. When six suppositories containing 20 percent of morphine hydrochloride in Theobroma oil are to be prepared, which of the following statement is correct (Given: Displacement value of morphine hydrochloride is 1.5, weight of each suppository is 1 g) [GPAT – 2020]
(a) The displacement value of morphine hydrochloride is to be considered
(b) The displacement values of both morphine hydrochloride and Theobroma oil are to be considered
(c) The displacement value of morphine hydrochloride is to be ignored
(d) The displacement value of Theobroma oil is to be considered
4. In case of suppositories base, SFI stands for [GPAT – 2019]
(a) Solidified Fatty Acid Indices
(b) Solid Fluid Indices
(c) Solidified Fatty Acid Incline
(d) Solid Fat Index
5. The displacement value is defined as [GPAT – 2016]
(a) Quantity of drug which displaces one part of the base
(b) Quantity of base which displaces one part of the drug
(c) Quantity of drug which displaces one part of the acid
(d) Quantity of base which displaces one part of the acid
6. Bougies are [GPAT – 2015]
(a) Rectal suppository
(b) Urethral suppository
(c) Hydrogel suppository
(d) None of these
7. The ideal saponification value for suppository base is [GPAT – 2014]
(a) 50–100
(b) 100–150
(c) 150–200
(d) 200–500
8. Match the following terms and their examples [GATE – 2006]
Group-I (Term)
1. Hydrophilic suppository base
2. Polymorphism
3. Film former used in the formation
4. Opaquant extender
Group-II (Example)
[P] Nitrocellulose
[Q] Titanium dioxide
[R] Cocoa butter or nail lacquer
[S] Polyethylene glycol
(a) 1-[P], 2-[Q], 3-[R], 4-[S]
(b) 1-[Q], 2-[P], 3-[R], 4-[S]
(c) 1-[R], 2-[S], 3-[Q], 4-[P]
(d) 1-[S], 2-[R], 3-[P], 4-[Q]
9. Which of the following is NOT an ideal property of bases
(a) Shall be non-irritant
(b) Shall not interfere in release
(c) Shall be compatible with drugs
(d) None of the above
155. Which of the following is an example of hydrophilic bases
(a) Hydrogenated oils
(b) Emulsified cocoa butter
(c) Glycero-gelatin base
(d) None of the above
ANSWER KEY
| 1-c | 2-d | 3-c | 4-d | 5-a | 6-b | 7-d | 8-d | 9-d | 10-c |
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