To prepare and dispense 10ml Magnesium sulphate enema

Object – To prepare and dispense 10ml Magnesium sulphate enema.

Reference – Gaud R.S. and Gupta G.D., Practical Pharmaceutics, CBS Publishers & Distributors Pvt. Ltd., 1^st Edition 2002, Reprint 2019, Page no. 62, 64.

Requirements –

• Chemicals – Magnesium sulphate.
• Glassware – 1 Beaker, 1 Measuring cylinder, Glass rod.

Theory –

Enemas are aqueous or oily solutions or suspension that are employed to evacuate the bowel, to influence the general system by absorption or to affect locally the seat of disease of introduced into the rectum for cleansing, therapeutic or diagnostic purpose. Cleansing preparation are used to evacuate feces in constipation before an operation. Enemas are usually given at body temperature in quantities of 1 to 2 pt injected slowly with a syringe. If they have to be retained in the intestine they should not be used in larger quantities than 6 fl. ounces for an adult.

Sodium chloride, sodium bicarbonate, sodium monohydrogen phosphate and sodium dihydrogen phosphate are used in enemas. Following substances may be used alone or in combination with each other or in combination with irritants such as soap. The action of enemas are classified as

1. By stimulation peristalsis because of their volume is large about 0.5 to 1.0 liter e.g., plain water, soap and turpentine enemas or other type of enemas causes osmotic retention of water in the bowel.
2. By lubricating impacted feces e.g. This type of enema is a smaller volume like olive and arachis oil enemas having volume about 100 to 500 ml.

Formula Table:

Procedure

1. Weigh all ingredients accurately.
2. Dissolve magnesium sulphate in purified water and shake.
3. Add sufficient purified water to produce 20ml.
4. If necessary, filter the enema.

Category: Saline laxative.

Storage: Store in a well closed container.

Use: Saline laxative.

Result: 10ml Magnesium sulphate enema had been prepared and dispensed.