To prepare and dispense 20ml cetrimide cream.

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Object – To prepare and dispense 20ml cetrimide cream.

Reference – Gaud R.S. and Gupta G.D., Practical Pharmaceutics, CBS Publishers & Distributors Pvt. Ltd., 1st Edition 2002, Reprint 2019, Page no. 23-24, 28.

Requirements –

  • Chemicals – Cetrimide, Cetostearyl alcohol, Liquid paraffin
  • Glassware – 2 Beaker, 1 Measuring cylinder, 1 Mortar pestle

Theory –

Cetrimide or alkyl-trimethyl ammonium bromide is an antiseptic which is a mixture of three quaternary, ammonium compounds: tetradonium bromide, cetrimonium bromide and laurtrimonium bromide. It is a creamy white, voluminous, free-flowing powder, a faint odour and has a bitter test. It is freely soluble in water but soluble in warm water and practically insoluble in solvent ether. It is used as a bactericide and astringent. Cetostearyl alcohol and liquid paraffin are used as emulsifying agents in this formulation. Purified water is act as a vehicle.

Formula Table:

S. No.IngredientsQuantity GivenQuantity Taken
1.Cetrimide0.5 gm0.1 gm
2.Cetostearyl alcohol5 gm1 gm
3.Liquid paraffin50 ml10 gm
4.Purified waterUpto 100 mlUpto 20 ml

Procedure

  1. Weight all the ingredients in the required quantity.
  2. Dissolve cetostearyl alcohol in the liquid paraffin with the help of heat in one beaker (Oily Phase).
  3. In another beaker at the same temperature dissolve cetrimide in purified water (Aqueous Phase).
  4. Add first beaker preparation (Oily Phase) in warm condition to second beaker preparation (Aqueous Phase).
  5. Stir the mixture until it cool.
  6. Transfer in a suitable container and then label.

Category: Antiseptic, Bactericide, Pharmaceutical aid

Storage: Store in a well closed container.

Use: For external use only.

Result: 20ml cetrimide cream had been prepared and dispensed.

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