Object – To prepare and dispense 20ml cetrimide cream.
Reference – Gaud R.S. and Gupta G.D., Practical Pharmaceutics, CBS Publishers & Distributors Pvt. Ltd., 1st Edition 2002, Reprint 2019, Page no. 23-24, 28.
Requirements –
- Chemicals – Cetrimide, Cetostearyl alcohol, Liquid paraffin
- Glassware – 2 Beaker, 1 Measuring cylinder, 1 Mortar pestle
Theory –
Cetrimide or alkyl-trimethyl ammonium bromide is an antiseptic which is a mixture of three quaternary, ammonium compounds: tetradonium bromide, cetrimonium bromide and laurtrimonium bromide. It is a creamy white, voluminous, free-flowing powder, a faint odour and has a bitter test. It is freely soluble in water but soluble in warm water and practically insoluble in solvent ether. It is used as a bactericide and astringent. Cetostearyl alcohol and liquid paraffin are used as emulsifying agents in this formulation. Purified water is act as a vehicle.
Formula Table:
| S. No. | Ingredients | Quantity Given | Quantity Taken |
| 1. | Cetrimide | 0.5 gm | 0.1 gm |
| 2. | Cetostearyl alcohol | 5 gm | 1 gm |
| 3. | Liquid paraffin | 50 ml | 10 gm |
| 4. | Purified water | Upto 100 ml | Upto 20 ml |
Procedure
- Weight all the ingredients in the required quantity.
- Dissolve cetostearyl alcohol in the liquid paraffin with the help of heat in one beaker (Oily Phase).
- In another beaker at the same temperature dissolve cetrimide in purified water (Aqueous Phase).
- Add first beaker preparation (Oily Phase) in warm condition to second beaker preparation (Aqueous Phase).
- Stir the mixture until it cool.
- Transfer in a suitable container and then label.
Category: Antiseptic, Bactericide, Pharmaceutical aid
Storage: Store in a well closed container.
Use: For external use only.
Result: 20ml cetrimide cream had been prepared and dispensed.
