To prepare and dispense 20ml magnesium hydroxide mixture.

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Object – To prepare and dispense 20ml magnesium hydroxide mixture.

Reference – Gaud R.S. and Gupta G.D., Practical Pharmaceutics, CBS Publishers & Distributors Pvt. Ltd., 1st Edition 2002, Reprint 2019, Page no. 220-221.

Requirements –

  • Chemicals – Magnesium sulphate, Light magnesium oxide, NaOH, Chloroform
  • Glassware – 1 Beaker, 1 Measuring cylinder, 1 Mortar pestle

Theory –

Pharmaceutical suspension is a coarse dispersion in which internal phase (therapeutically active ingredient) is dispersed uniformly throughout the external phase. The internal phase consisting of insoluble solid particles having a range of size (0.5 to 5 microns) which is maintained uniformly throughout the suspending vehicle with aid of single or combination of suspending agent. Magnesium hydroxide mixture cannot be prepared directly by suspending magnesium hydroxide powder in water because it absorbs carbon dioxide and moisture from the atmosphere. Hence it is prepared by the reaction between Magnesium Sulphate, Sodium Hydroxide and Light Magnesium Oxide. To improve the palatability of the mixture 0.1% of citric acid is added and chloroform act as preservative.

Formula Table:

S. No.IngredientsQuantity GivenQuantity Taken
1.Magnesium sulphate4.8 gm0.96 gm
2.Light magnesium oxide5.3 gm1.06 gm
3.Sodium Hydroxide1.5 gm0.3 gm
4.Chloroform0.3 ml0.06 ml
5.Purified waterUpto 100 mlUpto 20 ml

Procedure

  1. Dissolve the Sodium hydroxide in smaller amount of Purified Water.
  2. Add the Light Magnesium Oxide, mix to form a smooth cream and then add sufficient amount of Purified Water to produce final volume.
  3. Pour this suspension in a thin stream into a solution of the Magnesium Sulphate dissolved in Purified Water, stir continuously during the mixing.
  4. Allow the precipitate to subside, remove the clear liquid, transfer the residue to a calico strainer, (filter mesh made with porcelain) allow to drain and wash the precipitate with Purified Water until the washings give only a slight reaction for sulphates.
  5. Mix the washed precipitate with Purified Water, dissolve the Chloroform in the mixture and add sufficient amount of Purified Water to produce final volume.

Category: Antacid

Storage: Stored at cool place and do not store in refrigerator.

Use: For internal use only.

Result: 20ml magnesium hydroxide mixture had been prepared and dispensed.

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