Object – To prepare and dispense 10gm Carbopol gel.
Reference – Mehta R. M., Pharmaceutics-II, Vallabh Prakashan Pvt. Ltd., 4th Edition 2010, Page no. 188.
Requirements –
- Chemicals – Carbopol, Sodium benzoate, Calcium gluconate.
- Glassware – 2 Beaker, 1 Measuring cylinder
Theory –
Gels are transparent semi-solid preparations for external application to the skin or mucous membrane. Gels are semi-solid systems consisting of either suspension made up of small inorganic particles or large organic molecules in a liquid vehicle and appeared jelly-like by the addition of a gelling agent. They contain tragacanth, sodium alginate, pectin, starch, gelatin, cellulose derivatives, carbopol, and polyvinyl alcohol clays. There are numerous gelling agents varying in gelling ability.
Formula Table:
| S. No. | Ingredients | Quantity Given | Quantity Taken |
| 1. | Methyl salicylate | 10 gm | 0.1 gm |
| 2. | Menthol | 2 gm | 0.2 gm |
| 3. | SLS | 20.6 gm | 0.20 gm |
| 4. | Carbopol | 1 gm | 0.1 gm |
| 5. | Ethanol | 10 ml | 0.1 ml |
| 6. | Water | Upto 100 ml | Upto 10 ml |
| 7. | Preservative | Q.S. | Q.S. |
Procedure
- Weigh the calculated amount of ingredients.
- Take the weighed quantity of menthol, and methyl salicylate in a mortar, and triturate properly.
- Triturate eucalyptus oil and tween 20 in another mortar.
- Mix all the ingredients together and triturate vigorously.
Category: Anti-inflammatory
Storage: Store in a closed air tight container at room temperature, away from heat and moisture.
Use: For external use only.
Result: 10gm Carbopol gel had been prepared and dispensed.
